Next week I'll be starting my own lab at UCSF UCSFUrology! We’ll be using synthetic biology and functional genetic screens to understand antigen presentation and T-cell recognition in cancer and other diseases. We’d love for you to join us! More info at brunolabucsf.com

🎉 Excited to share a big part of my PhD work in Allon Klein Lab that took many, many years and my blood, sweat, and tears! 😅 We ask - What’s the role of cell division in the formation of initial cell types during early development ?🧐 biorxiv.org/content/10.110… 🧵 (1/14)

Excited to share the preprint of our latest work on Argonaute biology! We discovered that microRNA/siRNA sequences significantly impact the enzymatic activity of AGO proteins for RNAi, and determined its mechanistic basis and functional consequences. (1/6) biorxiv.org/content/10.110…

Looking for a #Postdoctoral Researcher to join the newly established Tsvetkov lab at the BIDMC Cancer Center , BIDMC Pathology to engage in cutting-edge science exploring questions at the intersection of metabolism, metal and cancer biology. Please reach out if interested and retweet 🙏

The Shrinivas lab is officially open :) Ethan and Mary - two amazing first-year PhD students are the first members with exciting projects that straddle genome organization, synthetic biology, and molecular computation! (super awesome logo designed by my brother)

For a brief period during embryonic development, cells must rely on messenger RNAs provided by the maternal genome. How do they regulate this limited supply of genetic material? In Developmental Cell, Bartel lab members detail this intricate regulatory system. wi.mit.edu/news/de-tail-i…

Check out our new open access paper on regulation of poly(A)-tail length and translation during oocyte maturation and early embryogenesis. Great collaboration with Jimmy Ly from the Iain Cheeseman lab. authors.elsevier.com/sd/article/S15…

New preprint from the lab!

Holy cow.

After years of planning & hard work, we are excited to present the structure of human AGO2 in the slicing conformation, paired to a fully complementary RNA target, revealing the structural basis of the reaction that powers RNAi. (1/5) @AMohamed_98 Seychelle Vos biorxiv.org/content/10.110…

Congrats to Gavin Schlissel Pulin Li with single-molecule imaging contribution from Domenic Narducci ASHansen Lab Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: pnas.org/doi/10.1073/pn…

I wonder if what JD Vance was trying to say re: PhDs and common sense is that academics don’t fully come into their own until postdoc. Maybe that’s what he meant.

Beyond thrilled to present our O-MAP—now *published* Nature Methods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵 nature.com/articles/s4159…

Our paper on the role of cell division in early embryonic development is out online! nature.com/articles/s4155… Lot more controls + some additional experiments to assess how changes in cell type proportions are reflected in embryo morphology.

How does one (signaling) arm know what the other is doing in the cell? Through a network of bHLH transcription factors obviously! Our work showing how neural stem cells integrate signals to coordinate a fate response is now out: cell.com/cell-reports/f…

Want to trace cell division histories in humans without gene editing? Here we develop MethylTree Nature Methods to use epimutations on DNA methylation for accurate lineage tracing across cell types, developmental stages and species. nature.com/articles/s4159…

Beautiful paper from sandynandagopal , Galit Lahav & colleagues. a seemingly “messy” circuit of dimerizing proteins (bHLH factors) can process a combinatorial input signals. Important step in more systematically understanding biological signal processing

Check out the latest work led by Matthew Hall in the Bartel lab! Matt solved a long-standing mystery about miRNA targeting, and drove the story to impressive mechanistic detail (1/2)

Multi-step genomics on single cells and live cultures in sub-nanoliter capsules biorxiv.org/content/10.110… #biorxiv_genomic

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason Sean McGeary Allon Klein Lab 1/20 doi.org/10.1101/2025.0…