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Excited that our single-cell eQTL study of HLA genes is out now in Nature Genetics! ⭐️ nature.com/articles/s4158… Huge thx to Soumya Raychaudhuri সৌম্য রায়চৌধুরী Saori Sakaue Yang Luo for their guidance Check out this great News & Views by the Gaffney lab describing the key points: nature.com/articles/s4158…

Excited to share that our paper is out in Cell! We "lnc" Xist ribonuceloproteins (RNPs) to the greater prevalence of autoimmune diseases in biological females. A wonderful multi-institutional collaboration with Howard Chang and many others! cell.com/cell/fulltext/…

Superb talks at AUPO-RPB symposium: RPB David Weeks Award: Patricia D'Amore (Harvard Ophthalmology Harvard Medical School ARVO) Resident-Fellow Research Awards: David Camacho (Penn Medicine), Rami Garbiel (Duke Eye Center), Christie Campla (Cleveland Clinic), Sean Ku Wang (Stanford Medicine)

Fascinating paper - gut bacteria can be found in retinal lesions of CRB1 mutant mice due to breakdown of blood-retina and intestinal epithelial barriers. Antibiotics reduce the lesions and retinal degeneration and may be worth trying in CRB1-associated retinal dystrophies

Excited to share our group's first manuscript describing new anatomical connections that allow the eyes to act as an "immunological window to the brain" 👁️🧠 (1/) nature.com/articles/s4158…

Congratulations to HHMI Investigator Howard Chang (Howard Chang), who was awarded the King Faisal Prize in Science for unveiling the intrinsic role of long non-coding RNAs in gene regulation and function. Learn more: hhmi.news/3JzF2UY

Just come out in J. Am. Chem. Soc. ! mRNA release is the key bottleneck for its delivery, and we solved this problem with the design of immolative guanidinium transporters (GSer-CARTs). A perfect blend of chemistry and biology in collaboration with Howard Chang Sean Ku Wang and others!

Incredible story from Andrew Dick and co on a noncomplement target for macular degeneration IRAK-M levels in the RPE decline with age and especially in AMD. Gene therapy restoring IRAK-M protects mice from retinal degeneration and may offer a new therapy science.org/doi/10.1126/sc…

The Dou lab at DukeIntegrativeImmunobiology Duke Department of Medicine is now recruiting new members! Join the team in deciphering the "lncs" between lncRNAs and autoimmunity! #rna #autoimmune #postdocjobs #AcademicTwitter careers.duke.edu/job/Durham-Pos…

Excited to announce my new lab at MCDB Michigan opening Jan 2025! 🎉 We’ll study how cells work together to shape the GI tract, with ties to regeneration & disease. Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org #DevBio #CellBio

Over the moon to join the Derm residency Penn Medicine after intern year Memorial Sloan Kettering Cancer Center! Incredibly grateful to my mentors, family, and friends for their unwavering support along the way. #Match2025

Happy to share our paper describing SPACE-seq - a new approach to spatial multiomics and lineage tracing - out today in PNASNews! 🧵(1/5) pnas.org/doi/10.1073/pn…

Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human development! biorxiv.org/content/10.110…. Read on for more 🧵 [1/16]

It's official - I am thrilled to share that I am joining MIT Biology, the Koch Institute at MIT, and MIT IMES as an Assistant Professor this fall! We will be a hybrid lab combining new technologies and computation to study ecDNA and tumor evolution. thejoneslaboratory.com