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Very excited this is out today...

Great first day with great science on alcohol associated liver disease: 3rd Johns Hopkins DELTA Center Symposium on Alcohol-associated Hepatitis: Pathogenesis, Treatment and Challenge

Dr. Ju Dong Yang Ju Dong Yang is corresponding author on the Nature Reviews Gastroenterology & Hepatology paper “Current and Emerging Strategies for the Prevention of Hepatocellular Carcinoma” reviewing preventive strategies & highlighting paths to reducing #hepatocellularcarcinoma. nature.com/articles/s4157…

Dr. Ju Dong Yang Ju Dong Yang is corresponding author on the Nature Reviews Gastroenterology & Hepatology paper “Current and Emerging Strategies for the Prevention of #Hepatocellular #Carcinoma.” This examines preventive strategies and categorizes them by their mechanism of action. nature.com/articles/s4157…

ALF announces recipients of 2024 Liver Scholar & Postdoctoral Research Fellowship Awards. These awards help early career scientists dedicated to understanding liver biology, discovering mechanisms of #liverdisease, advancing treatments for liver conditions liver.news/oss

Vijay Pandyarajan, MD, PhD - American Liver Foundation liverfoundation.org/medical-profes… congrats, Vijay! Thank American Liver Foundation, Greater New York for the support Cedars-Sinai Academic Medicine Cancer at Cedars-Sinai Cancer at Cedars-Sinai

New research out of Cedars-Sinai Medical Center demonstrated that steatotic liver modulated a fibrotic TME to enhance #metastatic cancer activity through a bidirectional regulation between CAFs and metastatic tumors. Journal of Clinical Investigation 🔁 bit.ly/4k2g4OT

JCI - Metastatic Tumor Growth in Steatotic Liver is Promoted by HAS2-Mediated Fibrotic Tumor Microenvironment jci.org/articles/view/… Our paper came out! We found one of the mechanism of how steatotic liver enhances CRC liver metastasis. Cancer at Cedars-Sinai Cedars-Sinai Academic Medicine

In colorectal cancer, liver metastasis is enhanced by fat build-up in the liver, but the mechanism was unclear. Ekihiro Seki & team Cedars-Sinai now show steatotic liver alters the fibrotic tumor environment, and inhibition of HA synthesis by 4-MU attenuates the effect in mice:

In colorectal cancer, liver metastasis is enhanced by fat build-up in the liver, but the mechanism was unclear. ASCI member Ekihiro Seki & team Cedars-Sinai now show steatotic liver alters the fibrotic tumor environment, and inhibition of HA synthesis by 4-MU attenuates the

New! Online now: Circulating glycerate predicts resilience to fructose-induced hepatic steatosis dlvr.it/TKJTX5

Get out your marshmallows for another chat by the fire! The Future of Biomedicine with Paul Noble Dr. Julie Louise Gerberding, Dr. John P.A. Ioannidis Victor Dzau, Dr. George D. Yancopoulos JointMeeting APSA #JointMeeting2025

Dr. Sergey Grivennikov Sergei Grivennikov will co-chair the #AACR225 mini-symposium “#Cancer Models: Mechanisms and Therapies” taking place today at 2:30pm CT. AACR

Dr. Jieun Kim will present “Chronic alcohol consumption promotes #pancreaticcancer liver metastasis in mice through PAD4-mediated pre-metastatic niche formation” at 2:50PM in the “Molecular Underpinning of #Metastasis” session. #AACR25 AACR Ekihiro Seki

Combination Therapy of TERN-501 and TERN-101 (THR-B and FXR) are now published Nature Medicine Naim Alkhouri Rohit Loomba #livertwitter Nabil Noureddin Yaron Rotman Ekihiro Seki nature.com/articles/s4159…

Out now: Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease: jci.org/articles/view/… Noemí Cabré Marcos Fernández Fondevila Bernd Schnabl & team UC San Diego reveal patients with alcohol-associated liver disease have increased expression of human ERVs

A new study in Nature Communications highlights the role of glutamate storage and release in mediating alcohol-related #steatohepatitis. go.nature.com/44yMRWp

The ERV/Zbp1 pathway as a potential approach in alcohol-associated liver disease. jci.org/articles/view/…

Super excited to share our recent publication in PNAS by Rui Zhang et al. describing how using CRISPR to remove pH sensitivity of NCX1 helps maintain its function during acidosis, which is cardioprotective during ischemia/reperfusion. pnas.org/doi/10.1073/pn…