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Another ICYMI #DDW2024 edition❗️ Our abstract found that severity of self-reported bloating correlates w/ excessive growth of coliforms, meeting the definition of #SIBO in the duodenum Digestive Disease Week Cedars-Sinai Academic Medicine

Latest MAST paper just published in Scientific Reports!! In an animal model, the optimal Rifaximin+NAC combo: 1) normalized stool consistency 2) ⬇️ small bowel bacterial levels 3) ⬇️ E. coli & Desulfovibrio spp. 4) normalized cytokine levels better than Rifaximin alone, suggesting

Take a look at our latest publication on intestinal methanogen overgrowth (IMO): ⬆️ Prevalence of constipation ⬇️ Prevalence of diarrhea ⬆️ severity of constipation sciencedirect.com/science/articl… CGH Cedars-Sinai Academic Medicine

We're getting close to using gases generated by gut microbiota to predict IBS symptoms. .Ali Rezaie MD MSc, Mark Pimentel MD, et al. found patients with IMO exhibit a higher rate and severity of constipation along with a lower rate and severity of diarrhea: cghjournal.org/article/S1542-…

A special day with patient 1000 in the REIMAGINE study. A massive effort to study the small intestinal #microbiome and new associations between single bacteria and human disease. Thanks to those who support this research! You will see great things in the coming months.

Reading recent comments on our posts about where we are for #IBS C, and D and #SIBO/#IMO/#ISO. Hopefully this helps. 1. We helped develop and study a new elemental diet (now available). 2. For IBS-D/SIBO, we have two drug therapies that are moving forward (one for hydrogen and

It's amazing what advanced food technology can achieve! Five decades since the creation of elemental diet and we finally made it palatable! #ACG204 Outstanding Research Award in the Small Intestine Category cdmcd.co/D8dKEW

Study demonstrates the contribution of gut pathobionts in releasing OMVs that traverse the mucosal barrier and, thus, promote #liver inflammation and fibrosis in PSC-IBD. 🔗 ow.ly/AnZi50TZi3h 🖋️ @MIB_GuentherLab

Serendipitous discoveries arise from curiosity in the face of the unexpected! Nicha Wongjarupong presenting our clinical trial at #FNM2024: Two weeks on an elemental diet led to fat-predominant weight loss, with sustained fat loss two weeks after reintroduction of regular food.

Humbled and honored to receive the AASLD 2024 abstract award. Grateful to my mentors, colleagues, and the AASLD community for their support and inspiration 🙏🙏🙏 #TLM2024 AASLD AASLD Foundation

Great news from #DDW2025. This will be a huge year. Big results on three new therapies for #SIBO/#IBS, #IMO (intestinal methanogen overgrowth) and #ISO (intestinal sulfide overproduction). Patients have been waiting a long time for drug therapies.

Excellent practical advice on managing GLP-1 RAs and endoscopy from our GI motility director, Ali Rezaie MD MSc! ⭐️ GLP-1 RAs objectively⬇️ gastric emptying For elective endoscopy: ⭐️ Hold GLP-1 RAs for 1 week ⭐️CLD for 1 day prior ⭐️Clear communication w/ anesthesia and pt

April is IBS Awareness Month. Let’s move beyond the myths and bring science and empathy together. IBS is a complex, organically-rooted condition and is not "all in your head". It’s time for a new narrative. #IBSAwarenessMonth #IBS #Microbiome #GutHealth

Food is not just fuel, it can be medicine! First prospective trial with a palatable elemental diet published CGH Why does this matter? Let’s walk through it 👇 #IBSAwarenessMonth #microbiome cghjournal.org/article/S1542-…

How to manage refractory SIBO? Mark Pimentel MD 💡Is it even SIBO? 🦠 💡Address the underlying cause-SIBO is a secondary process 💡Don’t be lazy, work it up! 🙌 💡Target the microtype: SIBO, IMO, ISO 💡Prokinetics to prevent relapse 💡Biofilm busters ie NAC #DDW2025 Digestive Disease Week

Challenge the guideline: 🌟Baclofen may NOT be safe for ALD compensated cirrhosis, per our multicenter cohort with lab data and longitudinal follow up 🌟Previous RCT that supported baclofen only had <40 pts using baclofen and was not powered for safety 🌟Call upon Motivational

How lucky am I to have this team?! Better, stronger, faster (& cute too). Great science… Even greater team. Yay to a DDW well done ! MAST Research Program Cedars-Sinai - #DDW2025 #gihealth #microbiome

#CGH4ALL 📣 💨 Excess methane = Constipation ↑,💩 Diarrhea↓ ➡️ Interesting implications for microbiome research! 🧠 This meta-analysis breaks down the GI symptom profile in IMO. 📲 Read more in CGH 🖇️ doi.org/10.1016/j.cgh.… Reported by Ariana Pereira Sepideh Mehravar, MD

Outpatient management of partial small bowel obstruction with oral palatable elemental diet. This could be a paradigm shift in how we manage recurrent pSBO and avoid hospitalizations. link.springer.com/article/10.100…