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Our latest study on the structural basis of deciphering AUA codon by isoleucine tRNAs was published at NatureStructMolBiol back-to-back with the paper by Gagnon Lab Matthieu Gagnon. Congratulation Akiyama-san! doi.org/10.1038/s41594…

Out just now The EMBO Journal: our cryo-EM structure of the native RanGTP-induced γ-TuRC-capped microtubule, revealing a surprisingly asymmetric minus end architecture with direct implications for microtubule regulation and modulation during spindle assembly. embopress.org/doi/full/10.10…

Our cryoEM of CBS filament conformations out in Nature Communications. Began decade ago when TJ McCorvie (@allostericstate on ☁️) purified oligomers. Fab collab Andre LB Ambrosio Sandra Dias seeing them in cells. Huge thanks Centre for Medicines Discovery Pfizer Inc. HCU Network America Wellcome for support x.com/NatureComms/st…

👉Do not forget - Translation UK at University of Surrey (close to London) is coming soon!

Angiogenin controls angiogenesis (et plus) by nicking tRNAs. But it’s barely active alone. We discovered how 80S ribosome unlocks Ang’s active site and “brings in” tRNAs. Congrats to Anna Loveland and collab. w/Allan Jacobson! nature.com/articles/s4158…

In this review, Karla Helena-Bueno and Lewis Chan introduce the concept of molecular hibernation to provide a brief overview of our knowledge about hibernation of biological molecules, such as ribosomes, RNA polymerases, Rubisco, and others #hibernation #ribosome #rubisco

Looking forward to the promising future of therapeutic tRNAs 🙂

Ever wanted to incorporate ncAAs into your protein but found the efficiency to be too low? Check out our new preprint, where we turned a simple observation in protein translation to an effective quadruplet codon translation strategy!

This new study by Yap lab @Ribo1214 identifies an RNase that can regulate ribosome stability in bacterial cells—it turns out that the widely conserved RNase YhaM can induce ribosome degradation in starved bacteria by digesting the mRNA of the ribosome hibernation factor HPF 👍

Polysome collapse and RNA condensation fluidize the cytoplasm dlvr.it/TB9lmf

In this review, we explore the potential impact of ribosome-targeting antibiotics on ribosome dormancy, a process that protects ribosomes from degradation in metabolically inactive cells: frontiersin.org/journals/micro…

Here, Ogawa lab explores how bacteria regulate the stability of their ribosomes: RNAse I likely degrades stalled, but not dormant or active ribosomes. What's more, dormant ribosomes seem to inhibit RNAse I by binding to it, somehow causing its "choking" 🙂biorxiv.org/content/10.110…

Here, Koch lab reports on bacterial ribosome hibernation. They show that the membrane-tethering hibernation factors YqjD/ElaB/YgaM, discovered by Wada in E. coli, are widely conserved in proteobacteria and likely target the ribosomal peptide tunnel👍 biorxiv.org/content/10.110…

Studying ribosomes? Read this work by Sergej Djuranovic and slavica pavlovic djuranovic—as it presents one of the most rapid and cost-efficient methods to isolate ribosomes from rare organisms or small biomass quantities 💪biorxiv.org/content/10.110…

Hibernating ribosomes have a complex social life in starved yeast cells: they assemble into intricate clusters and bind to mitochondria, illustrating how ribosomes hibernate in their natural habitat. More—in this fascinating study by Ahmad Jomaa: nature.com/articles/s4146…

This new preprint from the Cate lab provides insights into the fate of ribosomes in stationary archaea. Using an organism adapted to 95°C, they identify a protein called Dri, which appears to act as an archaea-specific ribosome hibernation factor: biorxiv.org/content/10.110…

Actinobacteria appear to possess a species-specific ribosome hibernation factor, found in Mycobacteria, that binds to the nascent tunnel of dormant ribosomes. More in this exciting study by Ojha and Agrawal lab: biorxiv.org/content/10.110…

Here, we show that bacterial ribosomes—viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. This divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.celr…