Cell-wall synthases contribute to bacterial cell-envelope integrity by actively repairing defects biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Interested in bacterial cell biology? Longing for sunshine in February? Then, this is the conference for you. A few travel awards still available. Please spread the word.

How do bacteria adapt to increase their fitness in starvation? This study shows that E. coli require less maintenance in starvation & survive longer, if they have previously grown slowly --> bit.ly/3cFxwEX from U Gerland TU München #QBio

Beautiful paper by the Gerland lab. Death rate grows exponentially with prior cell growth rate. Slower growth of Escherichia coli leads to longer survival in carbon starvation due to a decrease in the maintenance rate ncbi.nlm.nih.gov/pmc/articles/P…

Statistics tweeps: this paper estimates that being male increases the risk of dying of #COVID19 by almost 2-fold: nature.com/articles/s4158… Since risk clearly increases with age, I wonder whether the lower life expectancy of men could explain the sex difference? 1/2

Very cool paper by Severin Schink and others, pushing the Scott-Hwa global gene expression/growth paradigm to an exponential death phase. "In other words, it takes ~5.5 killed cells to make one new cell." cell.com/cell-systems/f…

Teaser for a phenomenal article by Rowan Jacobsen in Boston Magazine about SARS2 origins research and why it’s a challenging space to be in. Blown away by how well the article explains the mysteries surrounding COVID-19 and what’s at stake for science. Digital version in October!

Bacterial nanotubes are a hallmark of cell death, rather than living conduits for cargo, according to a paper from Libor Krasny's group just out in Nature Communications nature.com/articles/s4146…

Happy Halloween everyone! Stop by for some free candy!

Trade-offs in adaptation to glycolysis and gluconeogenesis result in a preferential flux direction in central metabolism biorxiv.org/cgi/content/sh… #bioRxiv

We have a meeting on quantitative microbial physiology June 13-15, 2022, in its birthplace - Copenhagen, Denmark. More info at indico.nbi.ku.dk/event/1592/. Please bookmark and RT.

The cell size and growth seminar continues next tuesday morning pst with a couple of exciting talks about bacteria. Growth, starvation, and death... Looking forward to it Ulrich Gerland and Severin Schink ;hosted by Matthew Swaffer Mike Lanz

We will be sneaking in some death into the cell size & growth seminar next week! Come join us!

Tomorrow I will give a talk about my major post-doc work. All unpublished data!

Re: amazing papers about lag phase... I just presented Severin Schink & Markus Basan's work on lag duration as a way of understanding substrate preference. It's so insightful and very well-written for such a complex topic. HT Otto X. Cordero biorxiv.org/content/biorxi…

The energy requirements of ion homeostasis determine the lifespan of starving bacteria biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Microbes face a series of fundamental trade-offs that limit their ability to optimize simultaneously for both glycolytic and gluconeogenic growth --> bit.ly/3zz6Gvx from M Basan Harvard Medical School & U Sauer IMSB_ETH #metabolism #FluxSensing #glycolysis

Nice systems-level comparison of #glycolysis vs #gluconeogenesis in E. coli, P. aeruginosa & P. putida by Severin Schink Uwe Sauer et al. IMSB_ETH that (partially) explains the length of lag phases on ≠ C sources Mol Syst Biol EMBO Press embopress.org/doi/full/10.15…

📢Registration is now open for the #Bacterialcell23 conference in sunny Cancun📢 Join Chairs Jie Xiao, @heathmurraylab, & our incredible speakers for the 4th edition in Feb 2023 🦠 #bacterialcell #cellbiology #celldivision #microbiology rb.gy/dv97ts

#Proteomics in E. coli under various growth conditions shows that a growth-starvation trade-off can be explained by resource investment to reduce cell envelope permeability, improving lifespan at the expense of growth ➡️ bit.ly/3FCyhkb M Basan Severin Schink Harvard Medical School