New intake of PhD students joining the 'NGC' group meeting and learning at the 'problems session' that chemistry (and its curly arrows and fish hooks) is a key foundation for interdisciplinary science. 100% true. don't @ me! Rosalind Franklin Institute

Had a great time at #HUPO2024 presenting our recent work using phosphoproteomics to characterise cellular quiescence in glioblastoma UCL Cancer Institute

Seriously, off to where the sky is blue, literaly.

Very proud of Innes Jarmson, who had the thesis viva yesterday! Congratulations, it has been a pleasure to supervise you. We wish you all the best for the future 🏆🍾🥂🥂🎉🎉🎉

It is finally OUT!! After a pandemic, lab moving across the country!, 1+ under review and >120 panels later. 🧵 cell.com/molecular-cell…

Delighted for WaelSSKamel. This was a rollercoaster ride. For more details and what we learned (very cool) see thread

New publication from Castello Lab and @FranklinSystems in Molecular Cell 🚨🚨🚨! We discover a group of nuclear #RBPs that travel to the cytoplasm to inhibit #virus #infection. We discover a novel #RNA mediated antiviral mechanism mediated by the U2snRNP cell.com/molecular-cell…

🦸 Hidden superheroes in our cells!? New research led by WaelSSKamel, Castello Lab & Rosalind Franklin Institute, has uncovered how a team of cellular “superheroes” leap into action to stop viruses in their tracks. Find out more: gla.ac.uk/research/az/cv… The study: cell.com/molecular-cell…

We are excited to share our new Nature Methods paper describing the Chip-Tip workflow for single-cell proteomics identifying >5,000 proteins in single cells, enabling PTM analysis without enrichment and throughput of up to 120 single cell samples per day: rdcu.be/d6qJe

First announcement! The Brixen Summer School is back and is, as usual, building up a strong speaker list. Thank you News@EuPA MSAID Thermo Fisher Biognosys Evosep SIGNATOPE

The Brixen summer school speaker list has been finalised. It's going to be another fantastic edition!

A Basic solution to a very common problem mcponline.org/article/S1535-…

🚨🚨News: Interested in the proteome configuration that makes a cell permissive or hostile to virus infection? Why mRNA levels do not fully reflect the proteome status after interferon treatment? See the new paper from Castello Lab and Mohammed lab mcponline.org/article/S1535-…

Deadline is fast approaching!

Here's an LC story from our lab. Unlike a lot of stories with questions as titles this one is a maybe yes! Interesting for those high throughput proteomics people! biorxiv.org/content/10.110…

So Nikita really wanted to present his poster (ThP648) on the omnitrap at #ASMS2025. Well with the power of the internet he can! Visa be damned. Also he is fresh and not destroyed by all the vendor hospitality...

We were just using NHS chemistry for some protein conjugation when we noticed some odd prominent side products. It turns out thio-nhs reagents (a major class of reagents) has some notable side reactions that happen all the time. nature.com/articles/s4146…

Proud to announce my first publication is out in PLOS Pathogens ! Huge thanks to my co-first author Wael, Brennan Lab CVR 🦠🕷🦟🔬🧫, and Castello Lab. The paper explores how tick RNA-binding proteins respond to UUKV infection, you can find the paper here dx.plos.org/10.1371/journa…

🚨 New paper in PLOS Pathogens! 🚨 Together with Brennan Lab CVR 🦠🕷🦟🔬🧫, we mapped – for the first time – how tick RNA-binding proteins rewire during virus infection. 283 proteins changed activity, revealing key players in viral fitness. Read here: doi.org/10.1371/journa…

We asked the question do solid particles have a role to play in the separation space within modern proteomics? Would these very small particles in short columns for fast gradients be a good idea for modern fast and sensitive MS? The answer was not no! pubs.acs.org/doi/10.1021/ac…