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I am excited to join Caltech Chemistry & Chemical Engineering Caltech as an Assistant Professor this November! The Fianu Lab will be a welcoming space for anyone interested in gene activity and genome stability. bit.ly/47gH9I7 We are looking for team members at all levels—please reach out!

Cool new preprint from Amgen 🧪🔬🧬 introducing LYMTACs, bifunctional small molecules that target cytosolic proteins to lysosomes biorxiv.org/content/10.110…

Just scratching the surface of what #Minflux can really do in tissue…:

It is out! #NanoPlex is the universal strategy for multiplexing any immunofluorescence using erasable #nanobodies from NanoTag. We showcase easy multiplexed STED, STORM, and 21-plex Confocal #Microscopy. Published in Nature Communications here: rdcu.be/dWvzO

A team led by Steffen Sahl & Stefan W. Hell MPI for Multidisciplinary Sciences and Max Planck Institute for Medical Research has succeeded in measuring distances within biomolecules using the #MINFLUX microscopy method, down to 1 nanometer and with Ångström precision. Read more in our press release: mpinat.mpg.de/4816514/pr_2419

Published in Science Magazine: "Direct optical measurement of intramolecular distances with angstrom precision" (Sahl et al.) science.org/doi/10.1126/sc… MPI for Multidisciplinary Sciences Max Planck Institute for Medical Research #Optics #Imaging #Microscopy #MINFLUX #Fluorescence

🥳 Exciting news! Thrilled to announce my new lab at IBDM @cnrs. 🎉 We use #LiveImaging to study how the dynamic #ovary makes healthy #eggs. 🔬🥚 Please RT & follow as we push the boundaries of #Fertility research! 🔗 bit.ly/3zQPEh7 #AcademicTwitter #NewPI

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in Current Biology, led by Ninadini Sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)

AATD affects thousands, causing liver & lung disease via protein aggregation. Our new preprint used #DeepVisualProteomics to study liver cells and reveals key AATD insights with clinical implications . Video and tweetorial Florian Rosenberger #Alpha1Awareness bit.ly/4hzl64o

Congratulations to *Dr.* Magda Magdalena Karpinska for her fantastic PhD defence! 🥳 More details on her PhD project will follow soon...

Many congratulations to Aiturgan @zhnbkv_ai and all the best for the future!

Bye, bye bleaching – hello #abberior LIVE HaloX! HaloX is an exchangeable label that transiently binds to #HaloTag fusion proteins, allowing long-term protein detection during live-cell imaging. Say goodbye to bleaching issues and capture extended imaging periods with ease! Read

I am beyond thrilled to share that I have successfully defended my PhD 🎓 MPI for Multidisciplinary Sciences Uni Göttingen. Heartfelt thanks to Grazvydas and Chromatin labeling and imaging lab members for their support and great times during my PhD. Grateful for everyone who have been by my side during this journey.

Labeling has become the be-all and end-all of superresolution.

After all these years, I still believe in it:

Published in PNAS: T. Moosmayer, K.A. Kiszka et al. (2024) "#MINFLUX fluorescence nanoscopy in biological tissue". Open access at pnas.org/doi/abs/10.107… including PSD95, presynaptic VGlut1 clustering and AMPAR clustering at the post-synapse MPI for Multidisciplinary Sciences Max Planck Institute for Medical Research

Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in Molecular Cell doi.org/10.1016/j.molc…

We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes. The proof-of-concept paper is on BioRxiv: doi.org/10.1101/2025.0… . Great job done by Marie Auvray at MPI for Multidisciplinary Sciences ! Enjoy reading!

Excited to share our preprint! We show MΦ- DNases clear NETs in atherosclerotic plaques and foamy MΦs impair this, leading to defective efferocytosis → worsening plaque progression. #Efferocytosis #atherosclerosis Mani Subramanian 🫀 William Harvey Research Institute Luiz Vasconcellos biorxiv.org/content/10.110…

🔬🧠We are pleased to announce that our work on Paralemmin-1 as a powerful regulator of the neuronal submembrane cytoskeleton has been published in Science Advances! Read the full study here: science.org/doi/10.1126/sc… #Neuroscience