SHARELA VEGA (@sharevega) 's Twitter Profile
SHARELA VEGA

@sharevega

Medical Oncology Resident, Vall d'Hebron Hospital

ID: 871018782814351360

calendar_today03-06-2017 15:00:35

150 Tweet

314 Followers

520 Following

Thatcher Heumann (@heumannthatcher) 's Twitter Profile Photo

KEYNOTE-966 GemCis+/-Pembro 1L BTC ▶️GC-Pem OS 12.7m v 10.9m (sig) ▶️ORR 29% in both, PFS ns but favors GC-Pem TOPAZ Differences ❇️stratified by geography ❇️gem maintenance ❇️blinded central review of response 🔥Solidifies GC+IO in 1L. Work to be done. 🔥If doing well, keep Gem

KEYNOTE-966 GemCis+/-Pembro 1L BTC
▶️GC-Pem OS 12.7m v 10.9m (sig)
▶️ORR 29% in both, PFS ns but favors GC-Pem

TOPAZ Differences
❇️stratified by geography
❇️gem maintenance
❇️blinded central review of response

🔥Solidifies GC+IO in 1L. Work to be done.
🔥If doing well, keep Gem
Asociación Española para el Estudio del Hígado (@aeehliver) 's Twitter Profile Photo

#AEEH2025. ➡️'Hepatolotoxicidad por inhibidores de CDK4/6 en cáncer de mama metastático (CMM)', con Mar Riveiro (ganadora de una de las #Becas Gilead-AEEH). ✔️Un estudio multicéntrico que todavía está en marcha. 🗣️"El manejo del #DILI por CDKi es heterogéneo, y su

#AEEH2025. 
➡️'Hepatolotoxicidad por inhibidores de CDK4/6 en cáncer de mama metastático (CMM)', con <a href="/mar_riveiro/">Mar Riveiro</a> (ganadora de una de las #Becas Gilead-AEEH).
✔️Un estudio multicéntrico que todavía está en marcha.
🗣️"El manejo del #DILI por CDKi es heterogéneo, y su
Arndt Vogel (@arndtvogel) 's Twitter Profile Photo

🔥CHMP recommended a conditional marketing authorisation for zanidatamab for the treatment of HER2-positive biliary tract cancer🔥 👉based on HERIZON-BTC: ORR 41% 👉Phs-III in 1st line ongoing ESMO - Eur. Oncology EASL Education ILCA Cholangiocarcinoma Foundation @livertwitter

🔥CHMP recommended  a conditional marketing authorisation for zanidatamab for the treatment of HER2-positive biliary tract cancer🔥
👉based on HERIZON-BTC: ORR 41%
👉Phs-III in 1st line ongoing
<a href="/myESMO/">ESMO - Eur. Oncology</a> <a href="/EASLedu/">EASL Education</a> <a href="/ILCAnews/">ILCA</a> <a href="/curecc/">Cholangiocarcinoma Foundation</a> @livertwitter
Vall d’Hebron Institute of Oncology (VHIO) (@vhio) 's Twitter Profile Photo

👏 Celebrating the strong contribution of our researchers from #VHIO’s Hereditary Cancer Genetics Group, led by judith balmaña, at #BRCA2025 in Montreal. 🎯 Advancing prevention and treatment in hereditary cancer through science and dedication.

👏 Celebrating the strong contribution of our researchers from #VHIO’s Hereditary Cancer Genetics Group, led by <a href="/judithbalmana/">judith balmaña</a>, at #BRCA2025 in Montreal. 

🎯 Advancing prevention and treatment in hereditary cancer through science and dedication.
Yakup Ergün (@dr_yakupergun) 's Twitter Profile Photo

The present and the future of immunotherapy in hepatocellular carcinoma and biliary tract cancers 💥Great review (Note: Medical writing support by Edra S.p.A. & AstraZeneca!) cancertreatmentreviews.com/article/S0305-…

The present and the future of immunotherapy in hepatocellular carcinoma and biliary tract cancers 

💥Great review

(Note: Medical writing support by Edra S.p.A. &amp; AstraZeneca!)

 cancertreatmentreviews.com/article/S0305-…
Arndt Vogel (@arndtvogel) 's Twitter Profile Photo

🔥EASL Clinical Practice Guidelines on the management of extrahepatic cholangiocarcinoma🔥 Journal of Hepatology doi.org/10.1016/j.jhep… 👉get the lastest update on the diagnosis and management of eCCA ESMO - Eur. Oncology EASL Education ILCA #livertwitter

🔥EASL Clinical Practice Guidelines on the management of extrahepatic cholangiocarcinoma🔥
<a href="/JHepatology/">Journal of Hepatology</a> 
doi.org/10.1016/j.jhep…
👉get the lastest update on the diagnosis and management of eCCA
<a href="/myESMO/">ESMO - Eur. Oncology</a> <a href="/EASLedu/">EASL Education</a> <a href="/ILCAnews/">ILCA</a> #livertwitter
Alejandro Garcia (@alej_garciamd) 's Twitter Profile Photo

We all know Jaume Capdevila magnificent presentation about Obrixtamig in epNECs. But let's go further! The first time the cut-off point of DLL3 positivity is revealed. We know it for Tarlatamab in SCLC? Is it better % or H-score? What do you think? Grupo GETNE ENETS NANETS

We all know <a href="/Ja_Capdevila/">Jaume Capdevila</a> magnificent presentation about Obrixtamig in epNECs. But let's go further! The first time the cut-off point of DLL3 positivity is revealed. We know it for Tarlatamab in SCLC? Is it better % or H-score? What do you think? <a href="/GrupoGetne/">Grupo GETNE</a> <a href="/ENETS_ORG/">ENETS</a> <a href="/NANETS1/">NANETS</a>
cinta hierro carbo (@chierrocarbo) 's Twitter Profile Photo

📢Practice-changing in 2L HER2+ GOJ/GC: DESTINY-Gastric04 trial 👁️T-Dxd vs paclitaxel+ramucirumab 🎯14.7 vs 11.4 m; HR 0.70 (p=0.004) ⚠️ILD/pneumonitis in 14% (mostly G1/2) 👣an exciting future to walk through with studies testing T-Dxd and zanidatamab upfront 📄NEJM today

📢Practice-changing in 2L HER2+ GOJ/GC: DESTINY-Gastric04 trial

👁️T-Dxd vs paclitaxel+ramucirumab
🎯14.7 vs 11.4 m; HR 0.70 (p=0.004)
⚠️ILD/pneumonitis in 14% (mostly G1/2)
👣an exciting future to walk through with studies testing T-Dxd and zanidatamab upfront 
📄NEJM today
Arndt Vogel (@arndtvogel) 's Twitter Profile Photo

Perioperative radiochemotherapy vs Gem/Cis in locally advanced gallbladder cancers #ASCO25 🔎POLCAGB phs-III 👉ORR 74% vs 35% 👉mEFS 10 vs 4.8 mo 👉mOS 21.8 vs 10 mo 🧐 small trial, but very interesting efficacy data in cT3/4 cN+ ESMO - Eur. Oncology @easledu ILCA Cholangiocarcinoma Foundation

Perioperative radiochemotherapy vs Gem/Cis in locally advanced gallbladder cancers
#ASCO25
🔎POLCAGB phs-III
👉ORR 74% vs 35%
👉mEFS 10 vs 4.8 mo
👉mOS 21.8 vs 10 mo
🧐 small trial, but very interesting efficacy data in cT3/4 cN+
<a href="/myESMO/">ESMO - Eur. Oncology</a> @easledu <a href="/ILCAnews/">ILCA</a> <a href="/curecc/">Cholangiocarcinoma Foundation</a>
Vall d’Hebron Institute of Oncology (VHIO) (@vhio) 's Twitter Profile Photo

🔴 Addition of Tumor Treating Fields to standard chemotherapy improves survival and pain-free survival in locally advanced pancreatic adenocarcinoma Findings co-authored by Teresa Macarulla presented at #ASCO25 & published in Journal of Clinical Oncology.  👉 linke.to/PANOVA-3ASOC25… ASCO

ilyas sahin, MD (@ilyassahinmd) 's Twitter Profile Photo

🔬 Three important cancer trials from #ASCO25, published today in NEJM. New findings in gastric, breast, and colon cancer. Quick highlights 👇 1-MATTERHORN (ASCO) In resectable gastric/GEJ cancer, adding perioperative durvalumab to FLOT improved 2-year event-free survival (67%

🔬 Three important cancer trials from #ASCO25, published today in <a href="/NEJM/">NEJM</a>. New findings in gastric, breast, and colon cancer. Quick highlights 👇

1-MATTERHORN (ASCO)
In resectable gastric/GEJ cancer, adding perioperative durvalumab to FLOT improved 2-year event-free survival (67%
Arndt Vogel (@arndtvogel) 's Twitter Profile Photo

🔥Plenary Discussion of LBA5🔥 📷 #ASCO2025 👏Great discussion by Sam Klempner 👉D-FLOT reached it's primary endpoint and will change clinical practice 👉More to come: from MATTERHORN to EVEREST ESMO - Eur. Oncology

🔥Plenary Discussion of LBA5🔥
📷 #ASCO2025 
👏Great discussion by <a href="/KlempnerSam/">Sam Klempner</a> 
👉D-FLOT reached it's primary endpoint and will change clinical practice
👉More to come: from MATTERHORN to EVEREST
<a href="/myESMO/">ESMO - Eur. Oncology</a>
Dr Amol Akhade (@suyogcancer) 's Twitter Profile Photo

Excellent summary slides for current evidence for pancreatic cancer treatment . Useful for quick reference. @asco #asco25 taken from talk by Dr Brian Wolpin 👍OncoAlert ONCO BRUNO

Excellent summary slides for current evidence for pancreatic cancer treatment . Useful for quick reference.  @asco #asco25 taken from talk by Dr Brian Wolpin 👍<a href="/OncoAlert/">OncoAlert</a> <a href="/brunolarvol/">ONCO BRUNO</a>
Natalia Tissera (@tisseranatalia_) 's Twitter Profile Photo

Couldn’t be prouder of you, Virginia Genovesi Congrats on presenting our study on ER in resected PDAC and for the travel grant! Key findings ⬇️ • 66% relapsed <1 yr • ER = worse OS • pT3–4 tumors more common in ER • KRAS mut (non-G12R) ↑ in ER Vall d’Hebron Institute of Oncology (VHIO) ESMO - Eur. Oncology #ESMOGI25

Couldn’t be prouder of you, <a href="/VGin93/">Virginia Genovesi</a> Congrats on presenting our study on ER in resected PDAC and for the travel grant!

Key findings ⬇️
• 66% relapsed &lt;1 yr
• ER = worse OS
• pT3–4 tumors more common in ER
• KRAS mut (non-G12R) ↑ in ER

<a href="/VHIO/">Vall d’Hebron Institute of Oncology (VHIO)</a> <a href="/myESMO/">ESMO - Eur. Oncology</a> #ESMOGI25
Teresa Macarulla (@macarullateresa) 's Twitter Profile Photo

John Bridgewater presented the results of ProvIDHe study, ivosidenib in the real world setting achieved a mPFS 4,7 months and mOS 15.5 months #ESMOAmbassadors ESMO - Eur. Oncology #ESMOGI25

John Bridgewater presented the results of ProvIDHe study, ivosidenib in the real world setting achieved a mPFS 4,7 months and mOS 15.5 months #ESMOAmbassadors <a href="/myESMO/">ESMO - Eur. Oncology</a> #ESMOGI25