Excellent work led by Muhammad Shariq Usman @DinoKazi UTSW Internal Medicine Chiefs

SGLT2i work in various combinations of HF, CKD & T2DM (fig) My fellowship w/ the great Javed Butler concludes with a 1st author paper in JACC! Truly honored to have learnt abt science & life from the best Excited for the next chapter UTSW Internal Medicine jacc.org/doi/10.1016/j.…

Effect of SGLT2 Inhibitors on Cardiovascular Outcomes Across Various Patient Populations: JACC Journals Here is weekend morning report to stay ahead of the published literature :) 🥸🥸🥸 Summary 👇👇👇

Meta-analysis SGLT2 inhibitors ⬇️ heart failure events & cardiovascular death in ppl of HF, T2DM and CKD Consistent in patients with varying combinations of these diseases jacc.org/doi/abs/10.101… Great paper by Mikhail Kosiborod Muthu Vaduganathan Javed Butler Dr. Deepak L. Bhatt et al

jacc.org/doi/abs/10.101… SGLT2 inhibitors reduce HF events and CV death in cohorts of HF, T2DM and CKD, and these effects appear consistent in patients with varying combinations of these diseases. JACC Journals #ADA2023

Dr Mary N Walsh Healio "Readers of this paper would do well to print the Central Illustration & display it in their clinic as a reminder of the benefits of SGLT2i ... There is no reason for therapeutic inertia in light of the evidence of benefit" healio.com/news/cardiolog…

In the EMPEROR trials, physiologic benefits of Empa quickly dissipated after blinded withdrawal of trial therapy. Read our paper Circulation ahajournals.org/doi/10.1161/CI… TL;DR: Benefits of SGLT2i persist after years and tx should be maintained! Javed Butler @UTSWNews UTSW Internal Medicine Chiefs

Adjudication or No Adjudication? We review current evidence from CV trials to help answer the question Javed Butler Shahzeb Khan Harriette Van Spall, MD MPH 🇨🇦 Steve Greene Dr. Deepak L. Bhatt @JJheart_doc UTSW Internal Medicine Chiefs @UTSWNews Read European Society of Cardiology Journals EHJ Editor-in-Chief: academic.oup.com/eurheartj/arti…

Debates in obesity management! Tomorrow 11/13 at 8 am in Room 204A! Please join Donna Ryan Shahzeb Khan Ali Aminian Sadeer Al-Kindi, MD Dr. Anne Thorndike, Dr. Layla Abushmat, Dr. Ian Neeland, Dr Amanda Vest #AHA23

Thrilled to be amongst the several residents representing UT Southwestern at AHA '23! We presented a study showing that heart rate variability <25ms is associated with a sharp increase in mortality and CV events in Black Americans (fig) @UTSWNews UTSW Internal Medicine Chiefs UTSW Internal Medicine Resident Research Programs

The prevalence of overweight and obesity has reached pandemic proportions, increasing the risk for overt cardiovascular disease. Read the cardiovascular effects of weight-loss interventions in #EHJ. doi.org/10.1093/eurhea… #obesity #GLP-1 #cardiotwitter European Society of Cardiology Journals European Society of Cardiology

After SELECT, it is clear that the new gen of weight loss meds will be crucial in the mgmt of CV risk Our review in EHJ covers everything cardiologists need to know about these meds 🔽 academic.oup.com/eurheartj/arti… Javed Butler @UTSWNews UTSW Internal Medicine Chiefs UTSW Heart @DinoKazi

The effect of #SGLT2i on left cardiac remodelling in #HFrEF: Systematic review and meta-analysis onlinelibrary.wiley.com/doi/full/10.10… European Society of Cardiology Journals

Our research letter in #EJHF highlighting the significance of WATCH-DM score in identifying subclinical cardiomyopathy among individuals with DM! A special thank you to ambarish for the great mentorship! onlinelibrary.wiley.com/doi/10.1002/ej…

"SGLT2 inhibitors being cardioprotective from a HF perspective was not a surprise and is a welcome addition to the post-MI population" - Javed Butler #ACC24 American College of Cardiology Baylor Scott & White Health #Cardiotwitter Read more👇 healio.com/news/cardiolog…

Our meta-analysis is now out in The Lancet Diabetes & Endocrinology: Effect of SGLT2 inhibitors on #heartfailure outcomes and cardiovascular death across the cardiometabolic disease spectrum. #cardiotwitter #cardiology #diabetes #cardioX Muhammad Shariq Usman Javed Butler Adrian “WE NEED RCTS!” Hernandez sciencedirect.com/science/articl…

With EMPACT-MI, the saga of SGLT2 inhibitors concludes! Our 📑 in The Lancet Diabetes & Endocrinology shows that SGLT2 inhibitors slash CV death & HF events in >50 subgroups within the cardiometabolic disease population thelancet.com/journals/landi… Javed Butler Dr. Deepak L. Bhatt Shahzeb Khan UTSW Internal Medicine Chiefs

Statistical Non-Significance, Likelihood ratio and the interpretation of RCT Evidence onlinejcf.com/article/S1071-… Counterpoint: Abandon or Reassess ? Interpreting Treatment Effects in Neutral Trials onlinejcf.com/article/S1071-…

Many HF patients would exchange some part of their remaining life for a better quality of life. However, it is difficult to measure and interpret how a patient 'feels' in HF trials. We discuss these challenges in our paper in Circulation Javed Butler ahajournals.org/doi/10.1161/CI…

What are the challenges in using and interpreting patient-reported outcomes in heart failure clinical trials? Muhammad Shariq Usman @ScrubsAndStats @javedbutler1 ahajournals.org/doi/full/10.11…