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1/ Delighted to share our review on Genetic Defects of Brain Immunity in Childhood Herpes Simplex Encephalitis (HSE), just out nature. Our expedition began in 2003, searching for monogenic defects underlying HSE (nature.com/articles/s4158…).

Félicitations à Jean-Laurent Casanova et Shen-Ying Zhang (Casanova Lab) pour la publication dans nature de la revue « Genetic defects of brain immunity in childhood herpes simplex encephalitis » 👉 pubmed.ncbi.nlm.nih.gov/39567785/

Rockefeller is looking to recruit the very best students from around the world to become tomorrow's scientific pioneers. Visit bit.ly/2Q1Lqv2 to learn about what makes Rockefeller such a special place to be a graduate student and how to apply. youtube.com/watch?v=M28Uv4…

A new paper from Vanessa Sancho-Shimizu and colleagues, reporting the finding of rare BTNL8 variants in MIS-C. 👏

We reported recessive DBR1 deficiency underlying brainstem viral encephalitis in humans in 2018 (sciencedirect.com/science/articl…) then 2024 (rupress.org/jem/article/22…). The molecular mechanism remained mysterious. Here it comes. Congrats to Daxing and team for the great findings!!!

Insights by Erika Valeri & @KajasteLab: Two works by Chan et al. (hubs.la/Q02-JGLM0), and Ru et al. (hubs.la/Q02-JK4r0), identify defective RNA processing as the root cause of impaired antiviral immunity against #SARSCoV2 in the human brainstem. hubs.la/Q02-JRPf0

A very insightful editorial written by Erika Valeri and @KajasteLab: Antiviral immunity lassoed down by excess RNA. So grateful to Journal of Experimental Medicine and the authors for highlighting our findings about human DBR1 deficiency. rupress.org/jem/article/22…

Human DBR1 deficiency impairs #StressGranule–dependent PKR antiviral immunity, say Shuo Ru, Daxing Gao and colleagues (University of Science and Technology of China): hubs.la/Q02-yPYS0 Casanova Lab Shen-Ying Zhang #Immunodeficiency #InnateImmunity #InfectiousDisease

1/ I am excited to share our new paper from Casanova Lab published today in Journal of Experimental Medicine about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem.20…).

The IUIS Inborn Errors Update is online!

Welcome to the future of #HumanImmunity research! Rockefeller U. Press and the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) are launching the Journal of Human Immunity (JHI)! Stay tuned for groundbreaking, #OpenAccess research! 👉 hubs.la/Q032QmF50

Welcome the journal of Human Immunity!

Congratulations to Rockefeller's Jean-Laurent Casanova (Casanova Lab) for winning the prestigious Novo Nordisk Prize!

The long-awaited 2024 update and phenotypic classification are here:

1/ One of the most intriguing enigmas of the #COVID19 pandemic was the sudden and unprecedented outbreak of chilblains that accompanied the early waves of #SARSCoV2 infections. Our new study in Journal of Experimental Medicine uncovers the underlying immunological mechanism   rupress.org/jem/article/22…

🔔 JHI is delighted to share the Abstracts from the 2025 Clinical Immunology Society's (CIS) Annual Meeting: Immune Deficiency & Dysregulation, May 1-4 in Philadelphia and online! 🔗 Explore the Abstracts 👉 hubs.la/Q03k2VPF0 #ClinicalImmunology #CISMeeting

A role of LY9 in immunity to infection learnt from human patients studies. Great finding!