🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

The Scripps Research Chemistry Department is hiring! Application Link: apply.interfolio.com/131532

Happy to share this total synthesis: not the end, but only the beginning. pubs.acs.org/doi/10.1021/ja…

Salvaging Salvinorin: From Hallucinogen to Potential Therapeutic through Chemical Synthesis Read it here: go.acs.org/6bj NEW First Reactions by Myles Smith & Bhawyanth Duvvuru @UTSWNews discussing work by Shenvi Lab Laura M Bohn & co-workers go.acs.org/6bk

Hi everyone! My PhD defense will be taking place this Thursday, October 12th at 9am PST. If you're interested in tuning in, you can find the zoom link below: scripps.zoom.us/j/97225538624

The final version of this Preprint has been published today in ACS Central Science : pubs.acs.org/doi/10.1021/ac…

Fall fashions have arrived. Inner-sphere is out, outer-sphere is in. A new ACS Publications Accounts from Simona Kotesova summarizes our group's development of first-row metal catalysis to enable fragment coupling en route to bioactive natural products. tinyurl.com/bde8pfs4

Spread the word! Come be our colleague! Scripps Chemistry is searching for a Tenure-Track Assistant Professor with a focus on organic chemistry and synthesis, broadly defined.

On today's episode, I am joined by Shenvi Lab of Scripps Research! We talk natural product synthesis, metal-hydride hydrogen atom transfer, the large overlap between writing music and organic synthesis, and much more.

2 papers posted today. #1 reports heterodimerization of benzyl radicals, generated and coupled by a single catalyst. tinyurl.com/2ej7zu3x The iron complex engages an alkene in two outer-sphere steps, in contrast to inner-sphere steps of precious metals. Congrats to the team!

#2: Had a blast collaborating with Baran Lab. Felt like old times. tinyurl.com/7heyrvka We report a single catalyst that quaternizes 3° radicals derived from RAEs or olefins. Very simple conditions: iron, reductant, base.

📢 *Calling all budding chemical biologist* Consider applying to the Program in Chemical Biology University of Michigan for your PhD!! Please reach out with any questions about this exceptional program.

Scripps Research chemists Ryan Shenvi and Guanghu Tong in the Shenvi Lab have modified the traditional poison picrotoxinin, significantly improving its stability and safety for potential neurological drugs, pesticides and anti-parasite treatments. ow.ly/wg3n50QkPa8

Ever wanted 3 grams of (–)-humulene oxide II? Neither did we. But OrgSyn came knocking and we couldn’t say no. orgsyn.org/Content/pdfs/p… Thanks for checking, @sarah_reisman and Emily Chen! #tbt Original gram-scale protocol in our JACS 2014 16788 paper.

This protocol saved my day a few years ago and works amazingly for even the trickiest olefin isomerisations!

I feel very honored to be recognized with this Rising Star Award. It would not have been possible without help from fantastic students, postdocs, collaborators, and colleagues.

Meet Stephan Freeman, #ARCSScholar Shenvi Lab Scripps Research where he is helping to develop new tools to access ‘natural product space,’ compounds typified by cellular metabolites. Stephan will be honored at our 2024 SOY Celebration in April. More info: san-diego.arcsfoundation.org/2024-SOY-Celeb…

So happy to see this work out today in Science Magazine! We showed that an iron catalyst and a silane can generate both 3° & 1° carbon radicals from olefins/RAEs and then couple them to make quaternary carbons! science.org/doi/epdf/10.11…

In this paper, 3rd year graduate student 李春雨 (Chunyu Li) synthesized 25 natural products (!!) using a method of in silico library selection. Chunyu is a new type of student in our lab, having seamlessly blended calculation and synthesis. Take a look: tinyurl.com/mryjxh2w

Congrats to Dylan and Stephen for their method to glycosylate cotylenol and access 14-3-3 protein-client molecular glues! tinyurl.com/2y45ck4n Donor linker design was aided by Stephen’s “autoDFT” and solved a common problem in terpenoid synthesis: contrasteric glycosylation.

If you like total synthesis and Wordle, check out Synthordle, a retrosynthetic analysis game created by Shenvi Lab associates Kevin Zong (GS 2) and Jonah Luo (HS sophomore!). rshenvi.github.io/synthordle/ Coming to Scripps Research Chemical Synthesis class in Winter ’25.