#MiamiEpigenetics22 Great opportunities for learning and connecting. Many thanks to the organizers Sylvester Comprehensive Cancer Center and the world renowned speakers 👏👏 😊😊

Kicking off day 2 with Polycomb & noncoding RNA in cancer, at the 5th Biennial Miami Cancer and Epigenetics Symposium🧬 #MiamiEpigenetics2022 Sylvester Comprehensive Cancer Center Asifa Akhtar GardiniLab Harvard Medical School Shiekhattar Lab

We had a great turnout this weekend at the 5th Biennial Miami Epigenetics and #Cancer Symposium with engaging talks from speakers representing the top #cancer #research institutions in the nation and internationally. #MiamiEpigenetics2022

Thrilled that so many experts came to Sylvester Comprehensive Cancer Center symposium to discuss their most promising and recent research findings AND brainstorm to establish collaborations and help the trainees advance their science and career!

Impactful symposium in Miami this weekend! Some of our very own Shiekhattar Lab, Lluis Morey, thecimminolab and Taylor Lab UM discussing the latest discoveries in cancer and epigenetics research. Sylvester Comprehensive Cancer Center #MiamiEpigenetics2022

Our new paper is out on Science Advances The Integrator complex regulates microRNA abundance through RISC loading science.org/doi/10.1126/sc… Well done Nina Kirstein and Sadat Dokaneheifard and all collaborators.

Human Integrator provides a quality checkpoint during elongation to facilitate RNA polymerase II processivity biorxiv.org/cgi/content/sh… #bioRxiv

Interestingly they show H3K4me3 is required to recruit integrator complex, which is essential for the eviction of paused RNAPII and transcriptional elongation.

What can machine learning do for your favorite protein complex? A lot! Especially if paired with proteomics and genomics. In collaboration with Wojtek Galej we characterized the 15th Integrator subunit! Shout out to Sarah Offley and Moritz Pfleiderer for leading this effort #transcription

Join us for a FUSION Conference on "Genome Regulation through RNA" next February (11-14) in Cancun! fusion-conferences.com/conference/155 The meeting will boast cutting-edge work on #epigenomics, #transcription, #lncRNAs & #smallRNAs biology, #genomeintegrity, #epitranscriptomics and more! (1)

Hello, check our new paper in BioRxiv. It describes new integrator module (INTS9/INTS11 and BRAT1) regulating the neurodevelopment program.

Explore emerging #CancerEpigenetics #CancerTherapy #Epigenomics research with field leaders Keystone Symposia Epigenetic Mechanisms and Cancer Treatment, this February in Santa Fe! keysym.us/KSCancerEpi24 #KSCancerEpi24

Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks biorxiv.org/cgi/content/sh… #biorxiv_molbio

Honored to contribute to this work with Stephen D. Nimer, MD. #TAF1 #Hematopoiesis Developmental Cell Sylvester Comprehensive Cancer Center

Our new paper is out on Molecular Cell !! We show that Integrator complex, is essential for RNA Polymerase II recruitment, pluripotency, and developmental gene regulation in mESCs. sciencedirect.com/science/articl… #StemCells #Transcription #DevelopmentalBiology #RNApolII

Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA dlvr.it/TMNCmm

For a quick summary, read the Research Briefing here: nature.com/articles/s4159…

Nature research paper: RNA N-glycosylation enables immune evasion and homeostatic efferocytosis go.nature.com/4m6slCP