Study sheds light on how ion channels work in cell membranes, pointing to potential new ways for improving the delivery of drugs in the body and treatment of diseases, according to a team led by Dr. Simon Scheuring (Scheuring Lab) of Weill Cornell Medicine Anesthesiology. bit.ly/45IrCPr

Using HS-AFM dynamic imaging we discovered among canonical tetrameric TRPV3 channel a small population of channels with non canonical pentameric assembly. The pentamers have an estimated lifetime of only ~3 minutes.

It is well established that proteins in the TRP family of ion channels assemble from four subunits. But do they always do this? A five-subunit structure has now been observed, and might be involved in channel regulation. go.nature.com/3sBvHa0

HS-AFM movie of a tetramer-to-pentamer transition: Protomer diffusing in the membrane and inserting a tetramer to result in a pentamer. Pentamers have an estimated lifetime of ~3 minutes only.

In this week’s Editors’ Choice piece, we highlight the work of Shifra Lansky, Scheuring Lab and colleagues in nature, showing that the ion channel TRPV3 switches between tetrameric and pentameric states.  Read a summary in #ScienceSignaling: scim.ag/4cs

Excited to announce that my paper from Scheruing lab Scheuring Lab has been published in Nature Communications! Thanks to all the authors Yining Jiang , Jingyu Zhan, and Di Xia. A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1 disq.us/t/4jkjnho

We studied, using HS-AFM, a unique protein, Bcs1. A transmembrane protein with a heptameric (!) AAA-ATPase ring, that transports a folded protein across the inner mitochondrial membrane. Yangang Pan Weill Cornell Medicine Anesthesiology Free: rdcu.be/dojkc nature.com/articles/s4146…

A monumental work by John Ingraham and team Generate:Biomedicines on Chroma✨ for protein design. Congrats!!! 🔥🎉🔥🎉 So excited to see it out, fully open source and with experimentally validated xtal structures! Perhaps cryo-EM of the giant complexes next? generatebiomedicines.com/chroma

Understanding the structural dynamics of ion channels will help researchers target them for therapeutic applications. Sarah Anderson, PhD reports on how Scheuring Lab Weill Cornell Medicine used microscopy techniques to probe pore dilation in the TRPV3 channel. ow.ly/ss0750QpjHL

HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics - now out NatureStructMolBiol - free link rdcu.be/dE0wf Yining Jiang Boudker Lab Molecular Biophysics Training Program WCM Office of the Research Dean Weill Cornell Medicine Anesthesiology Conformational landscape of a single molecule

Thrilled to announce our latest work in NatureStructMolBiol on HS-AFM single-molecule structural biology with Scheuring Lab ! Marching towards our long-standing goal, we've directly linked the conformations of a single molecule to its instantaneous activity... nature.com/articles/s4159…

rdcu.be/dPbig The cyanobacterial protein VIPP1 forms ESCRT-III-like structures on lipid bilayers Free link: rdcu.be/dO2GF Collaboration with Ben Engel, Michael Schroda, and Christoph Haselwandter labs.

This is fantastic! Variability of membrane protein oligomeric state may be much more common. The structural biology approach, investigating highly purified samples, could only result in finding very homogeneous populations. Cannot wait to read the paper and see more! ⭐️⭐️⭐️

Our study with Elena Rogoulenko in @NAR_Open shows #DNA flexibility impacts protein binding. Despite kinetic challenges, evolution ensures proteins effectively target and bind DNA. Check out Daniel Philosoph's cover art, hand-painted with real brushes! #ProteinDNA #ProteinStructures

Super exciting to share that our latest methodology development with Scheuring Lab just came out today in Nature Communications! In this work, we introduced a method to construct (pseudo-)3D AFM densities (3D-LAFM), and use these densities as external... nature.com/articles/s4146…

Check out our new paper in Nature Communications! We report a much improved structure of the TRPV3 pentamer, analyzing its high permeability capabilities and its mechanistic ability to reversibly transition to and from the canonical tetrameric state. Scheuring Lab nature.com/articles/s4146…

This is the most Israeli thing I’ve seen. Taken at the Weizmann Institute of Science, following the Iranian attack.