A super review of engineered T cells for cancer (CAR T and TILs) jamanetwork.com/journals/jama/… JAMA Jennifer N. Brudno, MD Dr Marcela Maus Christian Hinrichs

EXPLORING THE CHALLENGES OF DISTINGUISHING PUNCTATE INNER CHOROIDOPATHY FROM MULTIFOCAL CHOROIDITIS AND PANUVEITIS Park, Hyo Song MD; et. al. Retina 44(11):p 1869-1875, November 2024 journals.lww.com/retinajournal/… #retina

Always a pleasure to present in the Immune Epitope Database workshops and learn new cool features developed #iedbu2024

A distinct gut microbiome signature is associated with the risk of rheumatoid arthritis (RA), from the largest cohort of new RA to date ard.bmj.com/content/early/…

A single-cell atlas of aging tissue demonstrates shared multi-omics of aging and cancer hallmarks nature.com/articles/s4358… Nature Aging The Jackson Laboratory @justsaysinmice @OlgaAnczukow

Online now: T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics dlvr.it/TGYwfX

In June '24: At the moment of T cell activation, the presence, or lack, of nuclear envelope invaginations, which gather organelles, influences effector and memory fate decisions. buff.ly/3ZzruBG From Ben Hale, Berend Snijder et al. #Immunology #Tcells Science Magazine

The ocular immune system reflects broader immune evolution, from early pathogen defences to adaptive systems. This review examines immune privilege in the eye, framing it as part of a spectrum of tissue-specific immune responses. #Ophthalmology #OpenAccess nature.com/articles/s4143…

Immune cells can be programmed to deliver targeted therapies in models of brain and inflammatory disease. Learn more in a new #SciencePerspective: scim.ag/3OJP6gJ

New online! Antigen-specific immunotherapies for autoimmune disease go.nature.com/3ZKXbXs

New online! Molecular profiling for advancing precision rheumatology go.nature.com/3VOS0Vw

Enhancing immunity during ageing by targeting interactions within the tissue environment tinyurl.com/2m84cfjy This new Review discusses how inflammation and senescence drive each other during aging, leading to loss of immune function, and discusses approaches to address this

This Review in the February issue discusses progress with enhancing the activity of endogenous regulatory T cells or delivering them as cell-based therapies for allergy, autoimmunity and cancer nature.com/articles/s4157… rdcu.be/d80zV

Review NatRevRheumatol Antigen-driven T cell responses in rheumatic diseases: insights from T cell receptor repertoire studies nature.com/articles/s4158…

#Immunology out now Science Magazine Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases. buff.ly/3QvxSVf By Maxim Zaslavsky Maxim Zaslavsky, Erin Craig, Anshul Kundaje (anshulkundaje@bluesky) Scott_Boyd_Lab_Stanford et al.

For readers interested in approaches to reset the immune system to treat autoimmune diseases, here's a comprehensive review nature.com/articles/s4157… rdcu.be/elE4L

Review Nature Immunology The role of gut microbial metabolites in the T cell lifecycle nature.com/articles/s4159…

Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy? dlvr.it/TM4ncq #immunology

The emerging role of multiomics in aging research tandfonline.com/doi/abs/10.108…

A #CuttingEdge article shares the first antigen-less pro-vaccine for #autoimmune diseases that suppresses autoimmunity by expanding antigen-specific Treg cells in affected tissues. Read more about this potential universal autoimmune treatment in The JI: ow.ly/FLMk50WuPOv.