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Thanks very much for giving us the chance to share our commentary on an exciting project and a fast moving field!

Is slow heart rate or conduction block heritable? Check out our new meta-analysis Nature Genetics incl common (~1.3m individuals) + rare (~400k) variants for bradyarrhythmias and conduction dz. Co-led w/ Lu-Chen Weng Joel Rämö Sean Jurgens Broad Institute ! nature.com/articles/s4158…

Just how many diseases can you identify with a good old 12-lead #ECG? NEW npj Digital Medicine, co-led w/ Sam Freesun Friedman, RVpacing & xwang, we use an autoencoder to map ECG to phenome, finding associations btwn ECG & >600 conditions Broad Institute ML4H Mass General Heart LINK⬇️

What does your electric heart tell you about the entire human disease landscape? Our ECG PheWAS was just published in npj Digital Medicine! A phenome wide association study of a deep learned latent space from 100K+ ECGs meta analyzed in 3 external cohorts...

We are excited to share our latest work, "Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes," now published in JAMA Cardiology, led by the brilliant undergrad Akshaya Ravi! 🎉 jamanetwork.com/journals/jamac…

Excited to share more great work pioneered by Shino Kany UK Biobank now out in JACC Journals #Advances ! Guideline adherent activity, whether concentrated (“weekend warrior”) or more regular, is assoc w/ ⬇️ ⬇️ CMR-based visceral fat, a powerful marker of cardiometabolic health

Is the ECG secretly a sphygmomanometer? We trained a neural net to predict hypertension from ECGs and found it associated with many cardiovascular outcomes.

Thrilled to see this collaborative effort published! Many thanks to my brilliant collaborators and mentors

One of the most impressive applications of AI in medicine so far, has been its ability to "see" features in diagnostic modalities that we missed for decades. Example: AI trained on ECG —used >100 years— captures who has hypertension and a score from this model outperforms blood

Weekend warriors vs. regular exercisers: Both patterns of physical activity linked to lower visceral, epi and pericardial fat. No real difference if total activity is the same. So yes — cramming it into the weekend still counts! sciencedirect.com/science/articl…

High prevalence of HFpEF in patients referred for AF ablation - significant variation depending on the diagnostic tool used. --> Screen for HF in AF-patients and consider initiating additional HF therapy. authors.elsevier.com/a/1l5Z-7tD%7Ea… #JACCJournals #HFpEFinAF

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