המירוץ לתרופה לאלצהיימר / מתוך 'המעבדה', כאן11 הסכתים. שיחה עם פרופ' אינה סלוצקי, נשיאת האגודה למדעי המוח בישראל, ראש המחלקה לפיזיולוגיה ופרמקולוגיה, הפקולטה למדעי הרפואה והבריאות וביה"ס סגול למדעי המוח, אונ' ת"א. להאזנה: kan.org.il/content/kan/po… Inna Slutsky אוניברסיטת תל אביב Tel Aviv University

👀Claude handles an insane request: “Remove the squid” “The document appears to be the full text of the novel "All Quiet on the Western Front" by Erich Maria Remarque. It doesn't contain any mention of squid that I can see.” “Figure out a way to remove the 🦑​​​​​​​​​​​​​​​​“

Hierarchical Bayesian modeling of multi-region brain cell count data biorxiv.org/cgi/content/sh… #biorxiv_neursci

So excited 🤩 … in 'stealth mode' > 6 yr We combine SWIR imaging & data analysis for touchless continuous tracking of human #gaze direction & #pupil size in CLOSED EYES Paper 👇validates technology; next: towards clinical use #ICU #anesthesia #sleep rdcu.be/dP6QA

1/9 Seeing the Future: Anticipatory Eye Gaze as a Marker of Memory We developed a NO-REPORT paradigm for studying episodic-like memory for events occurring at specific places and times Daniel Yamin 🎗 FlavioSchmidig Omer Sharon Charan Ranganath biorxiv.org/content/10.110… A 🧵.. pls RT

Shocking 👇🏻 Did a top NIH official manipulate Alzheimer's and Parkinson’s studies for decades? | Science | AAAS science.org/content/articl…

After three rejections we have finally published our data that 4-week single housing is not stressful for adult male and female mice. Please use and cite to justify single housing in your experiments for the animal welfare commissions.  labanimres.biomedcentral.com/articles/10.11…

How do specific projection pathways of the LC-NE system mediate sleep awakenings? Tomorrow (Wed Oct 9 15:30) at #sfn2024 Noa Matosevich presents our latest research at the mini-symposium "Emerging Functions of Neuromodulation during Sleep" jneurosci.org/content/44/40/…

🚨📢 Excited to announce our new paper in Science Advances! We’ve uncovered how Shank3 mutations affect myelination in an autism mouse model and human iPSC-derived OPCs. 🧠💡 Check it out! science.org/doi/10.1126/sc…

Online now: NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics dlvr.it/TG3dYh

Another beautiful, mechanistic and thorough study from Inna Slutsky. Great work Anto!

1/I’m honored to finally share our new paper in Neuron ! Some good news during this challenging time here in Israel. We uncovered a new role for NMDA receptors in regulating spontaneous hippocampal network activity! 🤩doi.org/10.1016/j.neur…

TAU researchers find that the NMDA receptor (NMDAR)—long studied primarily for its role in learning & memory—also plays a crucial role in stabilizing brain activity. This may lead to innovative treatments for depression, #Alzheimer's disease, and epilepsy. english.tau.ac.il/research/brain…

What if you could target brain regions important for recovery after spinal cord injury with DBS? Can you say hypothamamus? Guess what Cho and colleagues from Switzerland did just that in a brilliant new paper Nature Medicine. Key Points: - People don't think about it, but guess

Let’s share some data! Yuval Nir 💔 🧵 We’re thrilled to announce our new paper in Scientific Data featuring an open iEEG dataset from two medical centers and an ML model for detecting interictal epileptiform discharges during sleep 🧠⚡ 👉 nature.com/articles/s4159…

Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal -synapse number and maturation -seizure susceptibility and hippocampal-prefrontal cortex coherence -segregation of inputs into the lateral geniculate nucleus -neuronal and astrocytic gene expression nature.com/articles/s4159…

Had such a great time at #ISFN! 3 full days of neuroscience and meeting old and new friends-what else could I ask for? Turns out, the Best Poster Award😉 I didnt take any pictures during the meeting, so here’s one from this morning, just before going back to the medical clerkship

Excited to share our new preprint out on biorxiv! We found a specific LC pathway that influences sensory evoked awakenings from NREM sleep. ⁦Yuval Nir 💔⁩ biorxiv.org/content/10.110…

Very excited to share the first paper from my lab. We engineered a new PTEN sensor that permits dynamic imaging in living cells. We showed that this allows to visualize PTEN activity with subcellular resolution in the intact brain. Now published in Nature Methods