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Oocytes rely on maternal mRNAs for development into healthy eggs. But where and how are these mRNAs stored? Our latest work in Science Magazine shows that mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment (MARDO). bit.ly/3MNQSf1 (1/9)

So excited this is now out in Science Advances. We discover a hidden satellite DNA array that barcodes mouse chromosome 7 and recruits KRAB-ZFP819 to remodel chromatin and regulate exit from totipotency. Spearheaded by Liane , thanks to all involved..

Dr. Shiya Cheng, @GerritAltmeppen, and a team in the Schuh Lab discovered that mammalian #oocytes store maternal #mRNAs around the mitochondria in a membraneless compartment with hydrogel-like properties. 📎 Science Magazine: bit.ly/3zApw6N 🎙️: bit.ly/3FyeAdp

For his discoveries in the field of cellular logistics, the World Laureates Forum honors Dirk Görlich with the #WLAPrize 2022 in the #lifescience or #medicine category. Many congrats 🍾! mpinat.mpg.de/4248913/pr_2231

Did you know that human and porcine #oocytes cluster their chromosomes before they assemble a spindle? Our latest study in Nature Cell Biology reveals the mechanism and function of this unusual stage of #meiosis. nature.com/articles/s4155… (1/8)

Congratulations to Ina and all the authors! Great work!

Our new paper in Cell answers a decades-old question: what is the function and composition of enigmatic structures called cytoplasmic lattices in mammalian oocytes? -> They are storage sites for essential proteins for the early embryo! bit.ly/45XwShG🧵(1/10)

such a wonderful work showing the magic of the FG phase, and the application of the in vitro experimental system. Congrats to all authors! nature.com/articles/s4158…

Also an interesting parallel work by Dickson et al, from the group of D. A. Jacques doi.org/10.1038/s41586…

Max Planck Institute for Multidisciplinary Sciences - How HIV smuggles its genetic material into the cell nucleus mpinat.mpg.de/4608591/pr_2403

1/ 📢New #paper alert! Ever wondered how mammalian #oocytes deal with protein #aggregation during their prolonged #life? Check it out in our new paper led by Gabriele Zaffagnini out today in Cell: doi.org/10.1016/j.cell… 👇🏽a thread:

How do oocytes endure protein aggregation during their long life? 🥚 Together with the BökeLab, we found specialized compartments called EndoLysosomal Vesicular Assemblies (ELVAs) that sequester & degrade protein aggregates to maintain homeostasis. cell.com/cell/fulltext/…

Check out our new paper Developmental Cell! Aberrant cortex contractions impact mammalian oocyte quality. sciencedirect.com/science/articl…

Now online! Mouse oocytes sequester aggregated proteins in degradative super-organelles dlvr.it/T3478m

Oocytes are arrested in prophase to give them enough time to grow and accumulate sufficient maternal components.🥚 Our Nature Communications study led by Shiya Cheng reveals two mechanisms repressing cyclin B1 translation to maintain this arrest. bit.ly/4fVHgMz (1/6)

Trim-Away reveals a surprising function of poly(A)-binding proteins in the control of mRNA translation.

Isn't it crazy that the oocyte can remain in the ovary for decades before it forms a fertilisable egg?🤯This pause is important for the oocyte to get bigger in size and store components for the embryo. But how is this pause established? Read the latest Nature Communications study from

As women age, their egg supply declines dramatically and #DNAdamage accumulates more and more. 🧬 But why do aged #oocytes struggle to repair this damage? Discover our latest findings, led by Ninadini Sharma MPI for Multidisciplinary Sciences, here: mpinat.mpg.de/4945984/pr_2504

Excited to share Liran 's latest work posted on bioRxiv Cell Biology ! Building on her previous research published in nature , She has now uncovered the molecular determinants that govern the HIV capsid's passage through the NPC barrier. Fascinating! biorxiv.org/content/10.110…