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Introducing antibody-lectin chimeras (AbLecs), a new bispecific modality for cancer immune therapy. Congrats postdoc ⁦Jessica Stark⁩ and former PhD student Melissa Gray on this beautiful work. Watch for Jessica on the academic job market this fall biorxiv.org/content/10.110…

Excited to share our new bioRxiv! We developed antibody-lectin (AbLec) chimeras as a modular molecular architecture to target sugars, or glycans, for cancer immunotherapy. 1/n tinyurl.com/5yw69eeu #glycotime Carolyn Bertozzi Sarafan ChEM-H Stanford Chemistry HHMI

To map cellular sources of the dynamic circulating proteome, we (Wei Wei (魏伟), Xuchao Lyu, Long Lab, Carolyn Bertozzi, and more) expanded our cell-type selective secretome strategy to generate a 21-cell type, 10-tissue map of exercise-regulated secretomes in mice.

🚨🚨New #mucinome preprint! We used glycoproteomics and MD simulations to understand TIM-3/4 stx/fxn! Buckle up for this wild ride that involved collaborative #glycotime efforts from so many, esp Joann Chongsaritsinsuk Alexandra Steigmeyer Keira E Mahoney mia 🧵👇biorxiv.org/content/10.110…

Congratulations #proudofalumni ⁦Judy Shon⁩ and ⁦Green Ahn⁩, both getting hooded today then off to postdoc positions with ⁦ElowitzLab⁩ ⁦Caltech⁩ and Baker lab ⁦Institute for Protein Design⁩, respectively 🎉

Want to sequence RNA from cells without killing them or deliver RNA programs from cell to cell? Today in Cell, we present RNA exporters, which package and secrete cellular RNA, for non-destructively monitoring cell dynamics by sequencing and delivering RNA authors.elsevier.com/sd/article/S00…

RNA is informant and agent. Controlled RNA export from cells could enable cell-cell delivery of functional and non-destructive tracking of cell dynamics. Our new paper, led by brilliant Felix Horns, engineers RNA export for both capabilities: authors.elsevier.com/sd/article/S00…

Congratulations collaborative team lead equally by ⁦Gabby Tender⁩⁦@KayvonPedram⁩ and ⁦Judy Shon⁩, w/coworkers from ⁦Heinz Läubli⁩ and Weaver labs. Mucins drive cancer progression; we drugged them with targeted mucin proteases. nature.com/articles/s4158…

🎉🎉Super excited to announce that our manuscript on T cell immunoglobulin and mucin-domain containing (TIM) proteins was published in Nature Communications! We used glycoproteomics to drive MD simulations and understand how #glycotime affects structure/function: doi.org/10.1038/s41467…

Excited to share this work from Christine Isadora Ng! Precise control over protein subcellular localization could have massive implications for gain-of-function therapeutic strategies. We showcase targeted relocalization activating molecules (TRAMs) for rewiring interactomes. (1/n)

Thank you Richard Beatson and Joy Burchell for this great perspective on our work on targeted mucinases Nature Biotechnology, led by Gabby Tender @KayvonPedram and Judy Shon Sarafan ChEM-H

Sharing the good news that our reagent for probing mucins by IHC, Western blots and flow cytometry, a catalytically inactive mutant of the mucin-specific protease StcE, is now available from Sigma-Aldrich 🎉 sigmaaldrich.com/US/en/product/…

Excited to share my PhD work, out now in Science Magazine ! What governs successful lysosomal degradation of membrane proteins mediated by extracellular degraders? Can we improve degradation efficacy? science.org/doi/10.1126/sc…🧵(1/n)

Out now on bioRxiv! In my first project in the ElowitzLab, we explore how competitive, "many-to-many" dimerization allows complex, multi-input, and cell-type-specific biochemical computations🧵↓ doi.org/10.1101/2023.1…

New preprint: Networks of dimerizing proteins turn out to be powerful computational systems. In tweetorial form here by Jacob Parres-Gold, who led this work with Benjamin Emert, Matt Levine, and Andrew Stuart.

Our paper on lineage motifs is now online at Developmental Cell 😀 We hope that this approach will be widely useful for anyone interested in analyzing tree-type datasets!

Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy. In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene

Excited our final version of Christine Isadora Ng's work on targeted protein relocalization is out today @nature! Molecular control over protein localization could offer new opportunities for therapeutics and biological discovery. Sarafan ChEM-H Stanford Chemistry nature.com/articles/s4158…

Thrilled to share our work on novo protein LYTAC(pLYTAC)/EndoTag in @nature! Using de novo protein design, we created endocytosis triggering binding proteins (EndoTags) to degrade extracellular targets and amplify receptor signaling. nature.com/articles/s4158…

Excited to share our new study in nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A Tony Wyss-Coray & Carolyn Bertozzi labs collaboration. 🍭🧠 #glycotime (1/12) nature.com/articles/s4158…