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Decommissioning a linac means we get to make electron trees! ⚡️🌲 These 3D ‘lightning bolt’ patterns are created when high-voltage electrons branch through acrylic, leaving behind a permanent fractal design #radonc

RACE-GB is out! Congrats to authors for FIRST RCT of RT in gallbladder cancer. N=135 w unresectable GBC, after 4c chemo, addition of RT (vs. obs) improved OS from 4 to 10 months. Several limitations (single center, chemo gem/cis & 4 mo) but OS benefit shouldn’t be ignored.

It took this entire wall of books to print out the human genome. Zoom in to see the nucleotide sequences. Pic taken at @EllisonInst

💡All about efficiency. Subcutaneous nivolumab now✅FDA approved across indications. Especially for combination regimens and long infusion/chair times, this route is appealing given how commonly these PD1⛔️immunotherapies are used in clinic. OncoAlert fda.gov/drugs/resource…

Burgeon 🔝

The 2001 The Nobel Prize laureate Prof. Sir Paul Nurse for his groundbreaking work on the cell cycle, will deliver a talk on ‘Controlling the Cell Cycle’ on 29.5 at 2.30 pm Tata Memorial Hospital. You can catch it live streamed on our YT channel as well! DAE India  youtube.com/@TataMemorialC…

Giant strides. 21.8 months OS in GB was unthought of!

This is a major story from #ASCO25. Randomized phase 3 trial of time of day of immunotherapy infusion. Randomized to infusion before or after 3pm. Early infusion far superior: PFS 11.3 vs 5.7 HR 0.42, OS HR 0.45! Impactful, pragmatic, not costly. This should be a bigger story.

🎉 Congratulations to Shriya Dhingra on receiving the HBNI Outstanding Student Award 2024! We’re sure you’ll continue to do well and make a difference for years to come! 👏

Absolutely insane amount of data in this resource from Chris Mason The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs biorxiv.org/content/10.110… Spatial data on 15million cells from 100 donors across multiple ages, mainly GI

👏 I saw an interesting anecdote and just looked up the reference. Literally before I was born, an oncologist very succinctly and elegantly summarized how we offer hope to our patients living with cancer... these words are still true today! pubmed.ncbi.nlm.nih.gov/18750361/

Forget how your biology textbooks depicted the endoplasmic reticulum. @hhmijanelia scientist Andrew Moore used our open graphics tool AGAVE to create this image showing the ER's outer membrane. The tool borrows animation studio techniques to create realistic light sources.

Viewpoint discusses how oncology drug development is shifting from immunotherapy to targeted therapies like antibody-drug conjugates and radioligand therapy. ja.ma/3GSEPOQ

Exciting times! Head and Neck Cancer: Elective Nodal De-Escalation open.substack.com/pub/protons101…

New data from the randomized PEMBRO-RT study demonstrate when an ICI-mediated Abscopal effect is most likely to occur in patients with stage IV NSCLC. Ralph Weichselbaum Sean Pitroda, M.D. Amy L. Cummings, MD PhD doi.org/10.1038/s43018…

𝑵𝒖𝒂𝒏𝒄𝒆𝒔 𝒐𝒇 𝑷𝒓𝒐𝒕𝒐𝒏 𝑩𝒆𝒂𝒎 𝑻𝒉𝒆𝒓𝒂𝒑𝒚: 𝑭𝒓𝒐𝒎 𝑪𝒐𝒎𝒎𝒊𝒔𝒔𝒊𝒐𝒏𝒊𝒏𝒈 𝒕𝒐 𝑪𝒍𝒊𝒏𝒊𝒄𝒔 XXII Tata Memorial Hospital Annual Radiotherapy Practicum & 1st TMC - IBA Proton Therapy Practicum 🗓 12-13 September 2025 📍ACTREC-TMC 🔗 Register tinyurl.com/46pmefum

Important re-irradiation lesson for #radonc residents: when you look at your DVH in EQD2 (like in MIM), the "V20" that you need to look at will change. Here's a DVH from a 60/30 plan shown as physical dose vs. EQD2. The DVH looks much better below 60 Gy & a bit worse above it.

Glad to share that our staff published 52 papers in July, spanning cancer prevention & treatment, managing complications, health policy & quality improvement, contributing to generating high quality Indian evidence for treating our patients. ACTREC-TMC Tata Memorial Centre, Varanasi (MPMMCC & HBCH) Cancer Research Institute - ACTREC

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