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Knowing how to give a good talk is a crucial skill to have, but it's mostly not formally taught very well. Here's a 🧵on my strategy for how to prepare for the presentation, actually present it, and then answer the questions.

This paper presents an improved approach for mapping single-cell RNA-seq reads with optimized transcriptomic references which markedly recovers previously missing gene expression data. Allan-Hermann Pool nature.com/articles/s4159…

Artificial intelligence for natural product drug discovery bit.ly/488vLOB A review by a team including Marnix Medema Serina Robinson #rogerlinington Gerard JP van Westen Hirsch Lab covering synergies between omics-based natural product discovery and computational drug design

Check out our comprehensive single-cell epigenomics analysis of human brain organoid development!!! Outstanding teamwork by Fides Zenk and Jonas (josch1@bsky), great collab Gray Camp! D-BSSE, ETH Zurich ETH Zurich EMBO

A reinforcement learning algorithm achieves superior #insulin titration optimization versus other deep learning models and standard clinical methods in a prospective cohort in a proof-of-concept feasibility trial nature.com/articles/s4159…

Online now: Dendritic cells as shepherds of T cell immunity in cancer dlvr.it/SwF3Wk

#Tumour intrinsic resistance mechanisms were identified in 30 patients with #multiplemyeloma who experienced relapse after treatment with anti-BCMA #CART cells and/or anti-BCMA bispecific T cell engagers (TCE), or anti-GPRC5D TCE. nizar jacques bahlis nature.com/articles/s4159…

Exercise-dependent regulation of the tumour microenvironment: nature.com/articles/nrc.2…

Drugs catch a ride through the blood–brain barrier - just out in Nature Biotechnology - how Denali Therapeutics @DyneTx & Bicycle Therapeutics are delivering biologics to the #CNS & how Voyager Therapeutics Capsida Biotherapeutics & Affinia Tx are doing so for gene therapy nature.com/articles/s4158… #biotech #neuroscience

Nature research paper: The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion go.nature.com/452R3ul

An advanced AI model based on AlphaFold predicts the pathogenicity of missense variants and assesses for all potential human single amino acid substitutions in the human proteome. #NBThighlight science.org/doi/10.1126/sc…

Mature B-cell malignancies #lymsm source: link.springer.com/article/10.100…

"The task is not to see what has never been seen before, but to think what has never been thought before about what you see every day." -- Erwin Schrödinger (1887 - 1961)

Excited and relieved to share with you our microglia-sufficient brain organoid work just online nature nature.com/articles/s4158… IPSC-derived microglia reprogram them metabolically! And make them mature faster!

Machine learning methods for variant effect prediction

My most-cited, never-accepted, ArXiv-only paper has over 1880 citations. "Deep Convolutional Networks on Graph-Structured Data" Mikael Henaff, Joan Bruna, Yann LeCun arxiv.org/abs/1506.05163

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Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis | Nature nature.com/articles/s4158…

Cellular adaptation to cancer therapy along a resistance continuum | Nature nature.com/articles/s4158…

What a beautiful story! So proud to be part of this study revealing microglia cells in the human PNS and their role in shaping neuronal soma size. Huge congrats to the whole team!