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The Panchenko Lab Panchenko lab develops and applies machine learning, molecular modeling, and molecular dynamics simulation methods to identify associations between the key epigenome components and to understand how their perturbation can lead to cancer. #BiophysicsWeek

Our lab is growing! Queens Pathology and Molecular Medicine Queen's Health Sciences. And a big welcome to our new trainees - Tiejun, Yosef and Austin!

DNA methylation: Precise modulation of chromatin structure and dynamic... sciencedirect.com/science/articl…

Shuxiang and Yunhui review controversial findings on how cytosine methylation dictates DNA flexibility and accessibility, nucleosome stability and dynamics

Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility dlvr.it/SXSHjZ

Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility dlvr.it/SXTlvk

a new preprint from our lab showing the effects of H2A.Z deposition biorxiv.org/content/10.110…

Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility biorxiv.org/content/10.110… #epigenetics #nucleosomes #histone #chromatin

DNA spontaneously unwraps thanks to H2A.Z! Check our discovery here biorxiv.org/content/10.110… bioRxiv #epigenetics #nucleosomes #histone #chromatin

check out Biophysical Society of Canada member Panchenko lab lab's new preprint on nucleosome dynamics: biorxiv.org/content/10.110…

Congratulations!

Beautiful fall day for a lab walk. Fed chickadees, spied snakes and made squirrelly friends. Queens Pathology and Molecular Medicine

Check this new paper out! A new approach to stratify histone classification and nomenclature: …eneticsandchromatin.biomedcentral.com/articles/10.11…

Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility dlvr.it/SjGNX8

Congrats to Shuxiang Li and Tiejun Wei on this study about H2AZ nucleosomes, their dynamics, stability and roles in transcription!

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors dlvr.it/T1PmjT

POLE variants promote genome-wide mutations in polypurine tracts - check out our paper by Daria Ostroverkhova in collaboration with Polina Shcherbakova's lab cell.com/cell-reports/f…

Our work on the identification of new pioneer transcription factors is out, in collaboration with Yunhui Peng David Landsman Teif Lab elifesciences.org/articles/88936

Check out a short paper by Daria Ostroverkhova and Yiru Sheng on pathogenicity predictors and their applicability to cancer: sciencedirect.com/science/articl…

Our new nucleosome positioning prediction method has been published. If you want to use it or see which nucleosomal features are deemed important: academic.oup.com/nar/advance-ar…