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1) Our new oncohistone study, “Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression” is published in pnas today! Congratulations to Sid Jain and our collaborative team! Doi: doi.org/10.1073/pnas.2…

An eloquent play by play of how 2 molecular alterations converge and modify prc2 activity to code an epigenetic program which yields tumors known to be formidable adversaries in the clinic.

Thank you, Giacomo! Our previous study, where we identified the function of EZHIP, serves as a nice primer for this follow-up: nature.com/articles/s4146…

We're excited that Molecular Cell selected our M.C. Escher-inspired artwork for the cover of their Nov 19 issue! Check out our new story about how H3K27M and EZHIP attenuate PRC2 activity in gliomas. tinyurl.com/y5cvcwsx Image credit: @cathylundgren. Thank you, Catherine!

Thank you, Melissa! It was a lot of fun working with you guys. And, thank you very much for testing my hypotheses over the years, many of which didn’t pan out 🙃

Come and join our lab! We have an opening for a motivated postdoc to study chromatin dynamics in cancer using biochemical and cell-based approaches. For more information about the lab’s research, see thelewislab.net/research. Send CV and cover letter to [email protected]

Congrats Melissa and Liz! Great to see this story out!

NEWS: We are HIRING! The Kadoch Lab Dana-Farber Harvard Medical School is looking to hire a new Research Associate! Undergraduates graduating this spring and aiming to spend 2 years in a lab and then attend graduate/medical school are encouraged to apply! Link: careers.dana-farber.org/job/research-t…

Interested in Polycomb and gene editing of histones - check out this nice work from our lab, pioneered by Aditya, Faizaan and Arun. Check also the accompanying News story by Scacchetti and Bonasio. nature.com/articles/s4158…

Congratulations, Chao!!

Excited to share my co-first ⁦Nature Aging paper from the latter half of my PhD on epigenetics of hematopoietic stem cell aging! Phenomenal team effort from the ⁦Adolfo Ferrando⁩ & ⁦Teresa Palomero labs!⁩!⁩ nature.com/articles/s4358…

All I want for Christmas is a mono-Q/S PC 1.6/5! Please Cytiva!

Wonderful collaboration and here’s to many more, Iannis Aifantis ! Very happy to see this body of joint work between our labs at Dana-Farber and NYU Langone Health out today in Molecular Cell !

Excited to share in Nature Chemical Biology our work revealing a repressive histone methylation ceiling using drug addiction mutations, & how we can exploit it as a vulnerability in EZH2-mut lymphoma. Big thanks to Hui Si, Ally Freedy, Liau Lab team, & Stephen Kissler! nature.com/articles/s4158…

Looking to study chromatin interactomes with proximity labeling? Check out our new paper in nature, where we combine our split-intein expertise with uMap technology from the MacMillan Group to map the microenvironment of chromatin state changes. nature.com/articles/s4158…

Congratulations to Harvard Chemical Biology PhD Program Kadoch Lab student, Jordan Otto Jagielski, Oana Ursu (@[email protected]) and Alex Wu on their exciting new Molecular Cell paper! Great collaboration with Regev lab using Perturb-seq to define functions of mSWI/SNF subunits and modules. cell.com/molecular-cell…

We had such a fun time with the The Muir Lab yesterday! Looking forward to all the exciting studies!! Kadoch Lab Cigall Kadoch claudia.gentile Aidan Quinn Hengyuan Liu

Fantastic project fuelled by Ivano Mocavini PhD student in our lab with Niccolò Arecco post-doc in Manuel Irimia It was not only great to see them working together, but we also learned a lot on alternative splicing and evolution during our discussions with Manu & Nicco doi.org/10.1101/2023.0…

Congratulations, Adrian and Orla!

Excited to share that my postdoc work is now published in Cancer Cell! This work, co-led by Fernando J. de Miguel and myself, reveals that mSWI/SNF complexes promote TKI resistance in #EGFR-mutant lung cancer. Dana-Farber Kadoch Lab Dana-Farber News sciencedirect.com/science/articl… Tweetorial ⬇️