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Great to see Alessandra Stangherlin preprint out!! Happy to have contributed and worked with amazing people O'Neill Lab !!! biorxiv.org/content/10.110…

This week on the Nature cover: Gut profiles. Screen of intestinal organoids reveals mechanisms of tissue regeneration. Browse the issue here: go.nature.com/33Dtj3u

I still can’t believe it!! Phenotypic landscape of 400k intestinal organoids. The 3k compound fingerprints allowed us to infer the first map of functional interactions and to translate our findings into intestinal regeneration in vivo nature.com/articles/s4158…

A very encouraging read. Thanks for your vulnerability, Anne Charmantier. I resonate a lot with the tension of squaring personal life / health matters with professional ambition and aspirations (1/n): nature.com/articles/d4158…

Function: Ligand combos are message “addressing” systems that can selectively activate different cell type(s) based on receptor expression. Outperforms 1-1 signaling arch. Works b/c ligand-receptor interactions “compute” complex responses.(Theory paper) biorxiv.org/content/10.110…

The problem is not people being uneducated. The problem is that people are educated just enough to believe what they have been taught, and not educated enough to question anything from what they have been taught. 🧠

Out now in Nature Cell Biology: Qiutan Yang, Prisca Liberali & collabs ISTAustria uncovered the forces that give the gut wall its classic brushlike appearance. The finding could help to reveal how the gut takes form and how this process goes awry in disease fmi.ch/news-events/ar…

Once thought to only regulate walking, the brain’s mesencephalic locomotor region also controls many other body movements, researchers in the Arber group show. The findings, published in Cell, could help improve therapies for Parkinson’s disease👉bit.ly/3zuD7d0

I am looking for a technical assistant to join me at CECAD Cologne in Cologne. We will be working on the biology of circadian rhythms. Please RT. jobs-uk-koeln.de/index.php?ac=j…

Finally out the work of my amazing supervisor Alessandra Stangherlin!!!💥 With the O'Neill Lab we showed that circadian rhythms in molecular crowding drive daily Na/K rhythms, allowing heart cells to beat faster when the heart clock expects us to be up and active! nature.com/articles/s4146…

Cellular ionic content shows temporal variations that occur to balance soluble proteome O'Neill Lab @Alestangh01 @MRC_LMB MRC-LMB Cell Biology go.nature.com/3B9AYEg

This is a great honour for my Lab. This award shows that diversity and inclusion can be the path to reach excellent results. Thanks for all the support I received on the way. Follow your passions 🤩 youtube.com/watch?v=iS2kQy…

Today, we and ⁦⁦Rebecca Ganetzky⁩ report ⁦NEJM⁩ a remarkable case of twin boys with euthyroid hyper-metabolism (low body weight despite high caloric intake), due to a de novo mutation in mito CV that uncouples respiration from ATP synthesis. nejm.org/doi/full/10.10…

mutscan - a flexible R package for efficient end-to-end analysis of multiplexed assays of variant effect data biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Happy to share new work from the Arber lab FMI science and Biozentrum, University of Basel done by Wuzhou Yang (inactive Twitter), me and Silvia Arber on a fine-grained map of the interaction between the cortex and medulla for the control of forelimb movements! sciencedirect.com/science/articl…

In a departure from biological rhythms, we’re excited to share our work describing the role of macromolecular assembly & condensation in the acute buffering of cellular water potential, published today nature. A thread: 1/16 nature.com/articles/s4158…

Join us in celebrating the launch of the Seattle Hub for Synthetic Biology with Allen Institute + UW Medicine. 🎉 Led by Jay Shendure, this new collaboration will build tech to understand temporal dynamics of cells & whole organism perturbation ➡️ czi.co/SeaSynBioLaunch #SeaSynBio

At #ASCB2024 today to speak in the session "Accelerating Discoveries in Cell Biology Using AI" about our Cell Observatory initiative to expand our understanding of subcellular physiology in the native multicellular environment by coupling advanced 4D imaging with AI. We're

If you are attending #CellBio2024 and are interested in understanding how the process of crypt morphogenesis is coordinated both in vivo and in organoids then come to my talk Wed Dec 18th in the subgroup “Organoids as tools to study the function of tissue in Health and Disease”

Check out our preprint on how initial cell-to-cell variability drives fate bistability and tissue patterning! 🧩 What a journey with Cornelia Schwayer David Brückner Edouard Hannezo and @prisca!!