Peter Simmonds (@simmonds_lab) 's Twitter Profile
Peter Simmonds

@simmonds_lab

Peter Simmonds runs a research group in University of Oxford. Very interested in the broader evolution of viruses and constraints under which they are placed.

ID: 873935320466804736

linkhttps://www.ndm.ox.ac.uk/principal-investigators/researcher/peter-simmonds calendar_today11-06-2017 16:09:52

107 Tweet

869 Followers

69 Following

Peter Simmonds (@simmonds_lab) 's Twitter Profile Photo

As some may know, Finnish doesn't have separate b's and p's, so new words may be a bit of a guess - usually right but not always!

Peter Simmonds (@simmonds_lab) 's Twitter Profile Photo

Very experimental but also very surprising, here is some evidence for excess C->U changes in a range of mammalian RNA viruses, potentially related to the much discussed phenomenon in SARS-CoV-2: doi.org/10.1371/journa… Consequences for virus evolution: interesting.....

Very experimental but also very surprising, here is some evidence for excess C->U changes in a range of mammalian RNA viruses, potentially related to the much discussed phenomenon in SARS-CoV-2:
doi.org/10.1371/journa… 
Consequences for virus evolution: interesting.....
Peter Simmonds (@simmonds_lab) 's Twitter Profile Photo

Very nice article comprehensively reviewing aspects of compositional bias in RNA viruses & interrelationships with still poorly characterised cellular mechanisms responding to RNA sequence motifs - ZAP, APOBECs, ADAR & many more, and selection biases from effects on translation

Heli Harvala (@harvalaheli) 's Twitter Profile Photo

Fantastic thread - we report here a total of 139 EV-D68 cases from Europe, most of them in September and numbers are likely to increase. A timely reminder that you will only find what you are looking for!

Tanya Golubchik (@tanyagolubchik) 's Twitter Profile Photo

Come and work with some fantastic people (Oxford/UCL) on using genomics to improve safety of transfusion and transplantation: jobs.ac.uk/job/CKU178/pro… jobs.ac.uk/job/CKV942/pos… Fully funded Oxford PhDs: ndm.ox.ac.uk/study/dphil-th… Fully funded UCL PhD: jobs.ac.uk/job/CKJ558/phd…

Virus infections and immunity (@awesome_viruses) 's Twitter Profile Photo

The largest study to date on the viruses residing within our tissues Unmasking the tissue-resident eukaryotic DNA virome in humans academic.oup.com/nar/advance-ar…

Jeremy Ratcliff (@jeremydratcliff) 's Twitter Profile Photo

Have you ever wondered how nucleic acid editing pathways (APOBEC, ADAR, and epitranscriptomics) might impact the adaptation of zoonotic viruses to humans? Of course you have! Lucky for you, we have a new review in COVIRO considering just that issue: authors.elsevier.com/c/1gtX36hO9tXx…

Derek Gatherer (@derekgatherer) 's Twitter Profile Photo

Before #COVID19, when was the last #coronavirus #pandemic? Some have argued for 1889-1892 for the zoonosis of human #OC43 from bovine coronavirus, but in our new paper: journals.plos.org/plosone/articl…, we suggest 1899-1900, based on a review and replication of existing molecular data.

Peter Simmonds (@simmonds_lab) 's Twitter Profile Photo

Here is my re-visiting of the C->U hypermutation phenomenon in SARS-CoV-2 genome 4 years from the start of the COVID pandemic: tinyurl.com/mw3ezp6c A trajectory of loss of C's / gain of U's, but weak 5' context effect and RNA structure dependence on edited sites. APOBEC 3A??

Here is my re-visiting of the C->U hypermutation phenomenon in SARS-CoV-2 genome 4 years from the start of the COVID pandemic:

tinyurl.com/mw3ezp6c

A trajectory of loss of C's / gain of U's, but weak 5' context effect and RNA structure dependence on edited sites. APOBEC 3A??