🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

Happy to share work with Hadi, Yao & Maxime TORTORA characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion biorxiv.org/content/10.110…

I'm thrilled to announce that my PhD thesis work from Bintu Lab on how the H3.3K36M oncohistone disrupts the establishment of epigenetic memory is now out in the latest issue of Molecular Cell. shorturl.at/X9IZG (1/4)

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in Current Biology, led by Ninadini Sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)

I’m excited to share the first preprint out of the Altemose Lab! This stems from a heroic effort by Dr. Matt Franklin Matt Franklin (who's on the job market!), who made surprising discoveries regarding some of the most mysterious regions of the genome. biorxiv.org/content/10.110…

We're finally out at Nature Communications. Congrats to Jiaxi (Jake) Zhao, Nick Lammers, YangJoon Kim, Simon Alamos and @gabrimartini_ny ! nature.com/articles/s4146…

The DelRosso Lab is starting UC San Francisco 1/2025 and is seeking applicants for a research postbac! We will be developing cutting edge high-throughput approaches to study the relationship between disordered protein interactions and transcription in human cells🔎 aprecruit.ucsf.edu/JPF05341

How are promoter interactions coordinated during cell differentiation? In our first paper, we investigate the temporal relationship between genome folding, transcription and histone modifications during ESC differentiation. (1)

Our new paper on epigenome editing is out! We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability nature.com/articles/s4158…

Thrilled to share our new preprint, 'A genome wide code to define cell-type specific CTCF binding and chromatin organization'. biorxiv.org/content/10.110…

Pre-print Alert! 🚨🚨 Do Glucocorticoid receptor (GR) condensates have a role in transcription? Check out the opera prima from PhD student Belén Benítez at Diego Presman and VLeviLab IFIBYNE 🇦🇷 CONICET - UBA IQUIBICEN - CONICET - UBA Exactas UBA 👇 doi.org/10.1101/2024.1… 1/7 Thread below 🧵🧵

🌟 Excited to share my PhD work, now on bioRxiv! 🎉 In Emmanuelle Fabre’s lab, we uncovered a novel role for the Smc5/6 complex, which binds microtubules to regulate pericentromeric chromatin dynamics. Check out our findings 🧵(1/5)

Beyond happy to share the most exciting findings of my PhD research in the StarkLab. 🤩 tinyurl.com/k6rbxjwn Our genome-wide silencer screen revealed that silencers are different from your typical regulatory DNA element. Find out more below 👇 (1/9)

Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…

My favorite paper of 2024!

In collaboration with Reuben Saunders, Jonathan Weissman's Lab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

📣Preprint alert! We have studied the formation of pair-wise and multi-way enhancer-promoter interactions in the #3Dgenome in a lymphoid-to-myeloid transdifferentiation system and learned interesting new things about their function in #GeneRegulation. 1/10 biorxiv.org/content/10.110…

In this review, Grace Bower & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their target genes rely on additional mechanisms to ensure robust gene activation during mammal development sciencedirect.com/science/articl…

New preprint on #CellularMemory and #3Dgenome! Can cells remember their past? If so, how do they record prior events? To address this fundamental question, we disrupted the chromatin state balance of mESCs and looked to whether they can recover. (1/8) biorxiv.org/content/10.110…

How does chromatin fold in different species? Is there an ubiquitous mechanism of chromatin folding in all species? We review published data to investigate the "Evolution and function of chromatin domains across the tree of life". rdcu.be/d1CxC