Regulation of biological functions such as cell migration depends not only on genes and signaling pathways but also on geometry. While it’s clear that cell shape matters, our new paper in Nature Cell Biology shows that organelle shape — in particular, the endoplasmic reticulum 1/

'How does something so seemingly inconsequential as a curvature of a gap, at the microscopic scale, end up dictating how cells move to heal a wound?' Read about how Simran Rawal (Tamal Das's lab) & colleagues probed cell responses to wound curvatures: tifrh.res.in/~sciencemedia/…

Next, Tamal Das Tata Institute of Fundamental Research revealed the influence of lysosomes in leader cell formation and the ER in supporting lamellipodial crawling and purse-string contraction, identifying them as key integrators of mechanochemical cues to drive collective cell migration. #MBIMPG2025