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Drugs for pseudomonas: piperacillin-tazobactam, cefepime , carbapenems except ertapenem, aminoglycosides, fluoroquinolones #medmicro

Burkholderia cepacia- CF lung infection. Associated with rapid progression of CF #medmicro

Stenotrophomonas- multidrug resistant nosocomial pathogen. Trimethoprim sulfamethoxazole drug of choice #medmicro

Aminoglycosides: gram negs including pseudomonas . By themselves not active against gram pos, but sometimes synergistic #medmicro

Aminoglycosides: no PO. Nephrotoxic. Ototoxic. Neuromuscular blockade. #medmicro

Aminoglycosides: protein synthesis inhibitor. Resistance commonly by drug modification. #medmicro

Aminoglycosides:Amikacin broader spectrum than genta and tobramycin. Save amikacin for when multidrug resistance suspected! #medmicro

Aminoglycosides: understand concentration dependent (As opposed to time dependent) activity and post-antibiotic effect. #medmicro

Article of interest: antibiotic use in cattle increased the pevalence of shiga toxin + E. coli CDC wwwnc.cdc.gov/eid/article/22… via CDC

SIRS: the definition doesn't include low BP as this is a late finding which appears when patient is in severe sepsis #medmicro

First step of managing SIRS or sepsis is fluids. Second step is antibiotics. Whenever possible get cultures before antibiotics #medmicro

Sepsis and SIRS: start broad antibiotics and do source control of infection #medmicro

Pathogenesis of sepsis starts with TLR recognizing PAMPs leading to NF-kB activating genes for pro and anti-inflammatory cytokines #medmicro

Complement and coagulation also co tribute to the sepsis response #medmicro

Impetigo: honey crusting; at sites of lack of skin integrity; S. aureus and GR A Strep #medmicro

Bullous impetigo: toxin producing S. Aureus #medmicro

Mupirocin is a topical anti S. Aureus antibiotic for mild impetigo #medmicro

staph scalded skin syndrome: extensive superficial blistering and exfoliation. Toxins mediated. #medmicro

Folliculitis: S. Aureus, Pseudomonas aeruginosa (hot tub), inflammatory/non-infectious. Topical or oral antibiotic #medmicro

Abscess, furuncle, and carbuncles require incision and drainage #medmicro