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A variant of the OAS1 gene, which encodes an enzyme that is critical for the innate immune response to viral infections, is associated with decreased risk of death in patients with #COVID19 brent richards McGill Medicine and Health Sciences go.nature.com/3soWEIs

This work is the collective effort of people from Biobanque québécoise de la COVID-19, especially brent richards Guillaume Butler-Laporte Tomoko Nakanishi, Vince Forgetta Adam and many thanks to the big data shared by COVID-19 Host Genetics Initiative !!

A great collaboration with Guillaume Butler-Laporte Tomoko Nakanishi Vince Forgetta Sirui Zhou Vincent Mooser and many others.

The famous 9p21 hotspot for diseases from CAD to aneurysm to cancer!

Super excited to announce my first paper as an MSc student McGill University: Circulating proteins to predict adverse COVID-19 outcomes medrxiv.org/content/10.110… is now up on medRxiv! Thanks to Sirui Zhou, Edgar Gonzalez-Kozlova & brent richards! #COVID19 Academic Chatter™ #AcademicTwitter

Huge congrats to Josh Backman, Manuel Ferreira, Goncalo Abecasis, Regeneron Genetics Center, and co. on nature 450k exome UK Biobank paper 🎉🎉🎉 Especially exciting to see ALL ancestries analyzed (not just EUR like most other UKB exome papers thus far) nature.com/articles/s4158…

Great opportunity to work and achieve as a postdoc at Richards lab brent richards at McGill University,Lady Davis Institute (strongly recommend from personal experience 😊) Apply here: linkedin.com/jobs/view/2758…

Now out in Science Magazine our work on ancestry-associated differences on the transcriptional response to influenza A (IAV) infection. Work led by the amazing Haley Randolph. science.org/doi/10.1126/sc…

I am excited to share our preprint with brent richards! We used Proteome-wide Mendelian randomization, colocalization, mediation analysis, and scRNA-seq to identify nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity. medrxiv.org/content/10.110…

Our pre-print describing the UK Biobank Pharma Proteomics Project (UKB-PPP) is now online! biorxiv.org/content/10.110… We identify 10k+ genetic associations w/ protein concentrations; 85% are new. The data should help drive discovery of new biomarkers, diagnostics & medicines.

ICYMI: Our Joint Postdoctoral Fellowship Program with CIHR will give postdoctoral trainees in the field of #HumanGenetics & #Bioinformatics the opportunity to utilize large-scale genomic & clinical data from our HostSeq Databank. Apply by July 14 ➡️ow.ly/r4bw50JhSaz

Join our team at McGill Genome and Lady Davis Institute!!

Combining genetics and metabolomics can provide tractable insights into disease causation. Here's our recent work in this field from Chen Yiheng and team using a large Metabolon dataset from Canadian Longitudinal Study on Aging (CLSA) in Nature Genetics nature.com/articles/s4158…

Excited to share our large-scale exome sequencing effort in Nature Genetics today. We showed that exome sequencing results can be combined with GWAS hits and our variant to gene mapping algorithm, the Effector Index, to identify high-yield targets. 👇 1/4 rdcu.be/diYqv

NEW PREPRINT! Interested in Mendelian randomization and proteomics? We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries! medrxiv.org/cgi/content/sh… Website: broad.io/protein_mr_atl…

Excited to share the first paper from my lab with amazing colleagues! We created a multi-ancestry protein-disease atlas of ~2,265 proteins and ~355 diseases using proteome-phenome-wide MR across three ancestries. Super star PhD student Chen-Yang Su will give an oral presentation

Interested in Mendelian randomization & proteomics? 🧬 On Nov 7 10:30am at #ASHG2024, I’ll talk about a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations we created! Join us in the session: Disease Insights from Omic-Wide Approaches

Congratulations to mcgill human genetics Professor Sirui Zhou for winning the Banting Discovery Foundation's 2025 Discovery Award for innovative biomedical health research projects!🏅 Her research on Ehlers-Danlos Syndrome will pave the way for better care. mcgill.ca/research/chann…