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There is input lag.

Our recent work just got posted on bioRxiv! Check it out from this thread:

We found Nr5a2 and Esrrb are important for triggering ZGA. The question is “how do these transcription factors trigger major ZGA?” (2/n)

See you soon! #EMBOmzt

Happy to have contributed a little to this awesome project! Great to see it published, congrats in particular to the first authors: (twitterless) Bart Dequeker and Matthias Scherr! MCMs can block cohesin! Lots of potential implications for chromatin biology, please have a read.

Our new biophysically interpretable machine learning approach has been published by Nature Biotechnology. This was a great collaborative effort. go.nature.com/3lAJlTZ bussemakerlab.org #ProBound

DeepPHiC: Predicting promoter-centered chromatin interactions using a novel deep learning approach biorxiv.org/content/10.110…

Glad to be the one who sorted out the fluorophore of the FISH probe 🥹

Fancy a field shake-up? nature.com/articles/s4158…

Protein–ligand binding affinity is predicted quantitatively from sequencing data go.nature.com/3lAJlTZ

Enjoyed reading this review covering: - CRE - systems biology in recent times - multiomics technology advances - cell type level epigenomics - role of applied ML/DL - #singlecell /nuc improving our understanding of CRE #Bioinformatics #MachineLearning nature.com/articles/s4157…

Here comes "spatial-ATAC-seq"!!! A wonderful collaboration between my lab at @YaleSEAS and GonçaloCasteloBranco at Karolinska Institutet #epigenetics #spatialomics #spatialbiology Spatial profiling of chromatin accessibility in mouse and human tissues | Nature nature.com/articles/s4158…

What are the rules of enhancer syntax? How flexible/constrained TF motif positions within enhancers are? How does the sequence context modulate the contribution of motifs to enhancer function? Excited to share our work together with Fanny Reiter addressing these questions! 1/19

What we all agree on: genomes evolve with time. But how do new genes get integrated into already excisting regulatory landscapes without disrupting them? Here is the answer - our latest contribution to 3D genomics: cell.com/cell/fulltext/…

Great to see our work on the roles of CBP/P300 and HDAC activities in H3K27ac dynamics and mouse MZT is out @ The EMBO Journal embopress.org/doi/full/10.15…

This amazing work couldn’t happen without the help and effort of the whole Tachibana lab! I’m am honor and excited to be part of this story 😊. Please see the 🧵 by Johanna Gassler for a brief summary.

Day 11/31 of #inktober2023 Prompt: WANDER Yellow Fluorescent Protein (Pdb: 1YFP). It lights up and lets us see how proteins wander through the cell. Next prompt is SPICEY. Please send suggestions. Protein Data Bank rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 Inktober #sciart

Our new paper in Cell answers a decades-old question: what is the function and composition of enigmatic structures called cytoplasmic lattices in mammalian oocytes? -> They are storage sites for essential proteins for the early embryo! bit.ly/45XwShG🧵(1/10)

🚀 Excited to share preprint as my last work in the Tachibana lab! Our study shows how the pioneer factor NR5A2 ensures robust gene activation through feed-forward regulatory loops with lineage-determining factors. A quick summary follows (1/n) biorxiv.org/content/10.110…

Finally, this work is a great collaboration within the Tachibana lab! 🎉 Huge thanks to: Chad Siwat Chad for all bioinformatic analysis. Eda (a talented student!) helped CUT&Tag and biochemistry. Adarsh Adarsh Mohanan helped testing KD. (11/n)