Can we do programmable computations in a chemical media where the chemistry does the computation? YES! This was an epic journey. Finally published: nature.com/articles/s4146…

Andy (Andy Lawrence) is now on stage showcasing his concept of stereoretentive enantioconvergent reactions at the 2nd edition of #ETCS at IIT Kharagpur #spandalab @Modhu Sudan Maji

Can machine learning models learn how to generate electron densities? Yes! nature.com/articles/s4358…

* Language is low bandwidth: less than 12 bytes/second. A person can read 270 words/minutes, or 4.5 words/second, which is 12 bytes/s (assuming 2 bytes per token and 0.75 words per token). A modern LLM is typically trained with 1x10^13 two-byte tokens, which is 2x10^13 bytes.

Nice breakthrough! Juan Nogales POLYBIO CIB Margarita Salas (CSIC) SusPlast-CSIC et al. have developed P. putida strains capable of converting plastics and lignin into up to 46% PHA/cell dry weight using a model driven approach #synbio #Sustainability Cell Reports cell.com/cell-reports/f…

Chemify’s first Chemifarm will be opening later this year. This will increase ability to make, mine, & discover in Chemical space by a factor of at least 10. Find out more chemify.io

Our new approach to enantioconvergent reactions is available Nature Chemistry. We hope the community finds it interesting and we’re excited to see how others might be able to exploit this concept! nature.com/articles/s4155… #Stereochemistry #AsymmetricSynthesis #Enantioconvergent

Can molecular complexity, the assembly index, be measured spectroscopically? Yes! pubs.acs.org/doi/10.1021/ac… #AssemblyTheory

A modified psychedelic found in the venom of a poisonous toad could be an effective treatment option for depression and anxiety, according to a study in mice published in nature. go.nature.com/3WsKtwD

Chuffed to share this work from my time as a postdoc in MaulideGroup! We show that β elimination can be overridden to allow σ-C–C bond between carbons separated by five bonds (i.e., ζ elimination). Check it out! science.org/doi/10.1126/sc…

🚨Asynchronous cloud-based delocalized closed-loop (ACDC) discovery of new chemical entities (laser dyes in this case) leveraging #Chemputation in this very cool (and impressive) paper. Go Chemify !

Some people misunderstand my stance on ‘AI’. AI is maths & I love maths. I don’t like the pseudo interpretation of AI being magic because I don’t believe in magic. The convolution of science with magic never ends well.

How can AI help natural product science, leveraging multimodal data? Read the Viewpoint from an international collaborative author team, spearheaded by our PhD student David Meijer, in Nat. Prod. Reports : pubs.rsc.org/en/Content/Art… Adam Skiredj Justin van der Hooft Connor W. Coley Mehdi Beniddir

Another amazing collaborative writing effort with Marnix Medema and Justin van der Hooft. We covered how AI, decision theory, and knowledge graphs could empower NP research. Thanks Adam Skiredj for creating this team effort. Congrats to David Meijer.

At Chemify we are unified by ONE vision. The digitization of chemistry. Molecules to code & code to molecules. This allows us to design, discover, & MAKE new molecules at scale efficiently & quickly.

Proof of Chemputation. arxiv.org/abs/2408.09171

Outstanding work from AsaphAharoniLab ! Always a pleasure to work on N&V with Niko Papon !

Yann Duroc est sur BlueSky Hicham C. science.org/doi/abs/10.112…

Very excited to see this PhD idea finally published as a review Nat. Prod. Reports. We classified all MIA oligomers (~1000) through their chemical logic assembly. 3 years of efforts. The structures were submitted The LOTUS Initiative kudos Adriano Rutz pubs.rsc.org/en/content/art…