
SlavoffLab
@slavoffl
We are a young Chemical Biology/RNA/Molecular Genetics lab at Yale Chemistry, working toward discovering the dark matter of the human genome.
ID: 1232053192982061056
24-02-2020 21:22:36
64 Tweet
298 Followers
158 Following

Very excited to team up with Lupoli Lab New York University NYU Chemistry in organizing the End of Year Chemical Biology Symposium, which will take place 6/6 Weill Cornell Medicine! Plenty short talks and poster presentations available for our NYC Chem Bio community! events.nyas.org/event/bc29f8d4ā¦




How do intrinsically disordered regions (IDRs) regulate protein function? Today in Molecular Cell, we show how the IDR of LSD1 acts as a fuzzy molecular switch to tune transcription factor interactions & control leukemia differentiation. (1/6) sciencedirect.com/science/articlā¦


Our labās first @chemcomm! We find that amidine-capped cysteine residues can be cleaved by trypsin to improve detection of tough-to-ID cys (e.g. resis found in very long sequences lacking K/R). Congrats to first author Samuel Ofori and team! pubs.rsc.org/en/content/artā¦




My first op-ed is out! Starting my faculty career was challenging in many ways, and one of those is that I had a leadership job that I didn't expect and wasn't (really) prepared for. Thanks to Inside Higher Ed for the chance to write about this and share some advice!

Led by the Yale Nanobiology Institute's Julien Berro, a team of scientists have received an #NIHHighRisk award to build a new sensor to target the mechanical properties of diseased cells bit.ly/berro-sensor NIH Common Fund




Check out our News&Views highlighting the work of Keriann Backus in Nature Chemical Biology : a new form of cellular stress and collateral degradation of proteins induced by electrophilic small molecule fragments. Work of Caroline Stanton + Kayla Nutsch, PhD rdcu.be/dXZpw

Thrilled to share our new study in Nature Chemical Biology describing the proteome-wide impacts of electrophile stress in the context of covalent fragments. Big congratulations to first authors Ashley Julio Ashley Julio and Flowreen Shikwana Flowreen Shikwana ! 1/5 nature.com/articles/s4158ā¦

Beyond thrilled to present our O-MAPānow *published* Nature Methods (!!!) O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. š§µ nature.com/articles/s4159ā¦


Ever wondered why we need respiratory supercomplexes? New findings from our lab, in collaboration with James A. Letts, show how a specialized supercomplex - the SC-XL - can help mitochondria overcome some respiratory defects & provide cardioprotective benefits. Studying


Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in Cell Reports, Faraz K Mardakheh and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

