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Our latest paper identifying a non-canonical role of CMT3 in preventing transposon silencing is online now! Congrats Jianjun Jiang Xuehua Zhong #PLOSGenetics: DNA methyltransferase CHROMOMETHYLASE3 prevents ONSEN transposon silencing under heat stress dx.plos.org/10.1371/journa…

Very cool new paper! Pathway conversion enables a double-lock mechanism to maintain DNA methylation and genome stability pnas.org/content/118/35…

Very cool new ONSEN paper!

OCT4 – Happy Pluripotency Day to those celebrating.

- Standing on the shoulders of Arabidopsis: success stories of application Javier Brumos @BrumosLab 🇪🇸 - Plant Epigenetics and Chromatin Dynamics Xuehua Zhong Xuehua Zhong 🇺🇸 Please contact organisers if you'd like to be involved....or submit an abstract :) aab.org.uk/submit-an-abst…

Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2 pnas.org/content/118/51… Now published in PNAS as an open access article.

Just scheduled my thesis defense 🤯

Biggest congratulations to my PhD mentor!! Very excited for this opportunity for you!

Sarah successfully defended her thesis work. Congratulations, Dr. Leichter!!!

Happy to see this story come out! Congratulations to Jianjun Jiang, Xuehua Zhong, and Jikui Song’s group.

An excellent protocol for profiling histone mods in Arabidopsis written by my very talented friend Ray Scheid. Well done Ray!

Henikoff, Nadiya Khyzha and Kami Ahmad introduce RT&Tag that enables mapping RNA molecules in proximity to a protein of interest in intact nuclei. OA paper: nature.com/articles/s4159…

Had the opportunity to hear Francis Collins talk about the future of genome science research! It’s a very exciting time to be in genomics! #uwgs22

Exciting to share latest paper in ⁦Nucleic Acids Res⁩. We developed CRISPR-based knock-in strategy to generate locus-specific epialle and investigate the mechanisms of interagenic heterochromatin establishment and inheritance. Congrats ⁦Zhang-wei Liu⁩ academic.oup.com/nar/advance-ar…

Our latest preprint on the mechanistic origin and evolution of CHH DNA methyltransferase CMT2 and how it diverged from CMT3 to achieve substrate specificity.

Biologists discover how plants evolved multiple ways to override genetic instructions @wustl Science Advances phys.org/news/2024-11-b…

Our work on evolution and functional divergence of DNA methyltransferases is out ⁦Science Advances⁩. Kudos to ⁦Jianjun Jiang⁩. We revealed how two closely related CMTs evolve and coordinately shape the non-CG methylation landscapes in plants. science.org/doi/10.1126/sc…

Out in Science 🧬! Using FFPE-CUTAC to profile RNAPII, we discovered that histone gene hypertranscription predicts rapid cancer recurrence and is linked to chromosome losses in meningioma and breast cancer. One more step to unraveling cancer progression! science.org/doi/10.1126/sc…

My paper on profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&Tag is officially out at Molecular Cell. Check it out! cell.com/molecular-cell…