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Delivery of RNA with PEG-peptide coacervates. Stronger expression (b) vs LNP (c). And working in vivo 😎 Collab with Ali Miserez @ NTU pubs.acs.org/doi/10.1021/ac…

A new and simple model-free method to analyze smFRET experiments. Protein dynamics from nano- to milliseconds without the nasty diffusion decays in standard FCS experiments - kudos to the great Ivan Terterov! Have a look! nature.com/articles/s4146…

Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates. nature.com/articles/s4155…

SNAP-tag is a widespread tool for labelling protein for bioimaging. An article published in Nature Chemical Biology presents SNAP-tag2 with increased labelling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging. go.nature.com/4eARnXz

Highlighting #DBTIndiaAllianceSuccessStories—noteworthy research and practical innovations powered by Department of Biotechnology and DBT/WT India Alliance, creating real-world impact. Meet Dr. Rachna Chaba, Professor in the Department of Biological Sciences at IISER, Mohali. Her work uncovers how E.

Our new work bioRxiv 🔗biorxiv.org/cgi/content/sh… BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. Adilgazy Semeigazin, MSc Katsuhiko Minami Masa A. Shimazoe

We have a Project Associate position on an ANRF project aiming at analyzing the single-molecule dynamics of functional RNAs in the LLPS environment. If you are interested in RNA biophysics, biochemistry or LLPS, please apply! Deadline: 20th July sites.google.com/view/functiona…

Before we’ve lost what we can’t rebuild: Hope for prion disease asbmb.org/asbmb-today/sc…

Our latest Biomacromolecules from Department of Chemical Sciences IISER Mohali congrats Shikha Priyanka for this very intriguing study. Thanks Anusandhan National Research Foundation for funding. Inversion of Enzymatic Enantiocatalysis Mediated by Biomolecular Condensates | Biomacromolecules pubs.acs.org/doi/10.1021/ac…

We’re back with a fantastic event! 🤩 "From Fold to Fail: How Proteins Go Rogue in Molecular Mayhem" 🪢 👨‍🔬 Dr. Samrat Mukhopadhyay, IISER Mohali 🗓️ July 20, 2025 🕥 10:30 AM IST 🎟️ Register: shorturl.at/epH9M E-certificates for attendees! #proteins #dbt #biochem #iiser

I'm looking forward to interacting with students & postdoctoral fellows on Sunday, July 20, at 10:30 AM (Delhi/Mumbai), 2 PM (Tokyo), 6 AM (London), 1 AM (New York) & 10 PM, July 19 (San Francisco). Thanks to the.scicomm.synapse for organizing this event. thescicommsynapse.in/event-details/…

Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy: nature.com/articles/s4159…

Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism biorxiv.org/content/10.110…

Happy to share our latest review article, highlighting how phase separation—driven by protein–protein and protein–RNA interactions—underpins the organization of ribosome assembly within the nucleolus. sciencedirect.com/science/articl…

It was wonderful to speak with the.scicomm.synapse yesterday. If you want to watch my interview, here's the link (duration: 1h40m; if you want, you can watch it at a 1.25x playback speed). youtube.com/live/6V1OOnctq…

Biomolecular condensates as regulators of enzymatic reactions: nature.com/articles/s4428…

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism biorxiv.org/content/10.110…

If you're tired of AI and stuff...we published CRISPR-based protocols that you can actually use to delete alpha-synuclein (~100% efficiency) or knock it into endogenous locus (~53% eff) in cultured neurons: star-protocols.cell.com/protocols/4339

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In Cell, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. sciencedirect.com/science/articl…

Ever wondered why nucleoli often have such complex shapes—despite behaving like liquids? If liquids tend to form spheres, why don’t nucleoli? What shapes them? We explore this in our latest preprint EMBL. Great work led by Daja Schichler & Yuki Hayashi! biorxiv.org/content/10.110…