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Insights into the physiological relevance of microexons 🔵 in pancreatic islets 🟢 by Jonàs Juan-Mateu, Manuel Irimia et al. Nice colourful cover too.

No more doubts pre-mRNA alternative splicing contributes to protein diversity.

Pleased to share the peer-reviewed version of our work on Insplico with André Gohr, Luis Pedro Iñiguez , @antonio_torm & Manuel Irimia out in Nucleic Acids Res doi.org/10.1093/nar/gk…

The peer-reviewed version of our paper on intron splicing order and Insplico is out Nucleic Acids Res! academic.oup.com/nar/advance-ar…

We suggest this alternatively spliced exon helps shaping the epigenetic landscape by focussing H3K27 methylation at target sites 🔍. SUZ12 exon 4 is an example of how highly alternative exons (𝑷𝒂𝒏𝑨𝑺) can help diversify the proteome by acting as gene function splitters. 9/9

🚨 New pre-print from the lab! Alternative splicing decouples local from global PRC2 activity Great work from Niccolò Arecco and Ivano Mocavini, in close collaboration with the Polycomb masters of the Di Croce Lab at Centre for Genomic Regulation (CRG)! Tweetorial by Niccolò Arecco. Additional #PanAS thoughts 👇 1/5

Interested in transcriptome diversity? Check out Emma (Finn) Jones, Ph.D. and co-authors' review just published in Briefings in Functional Genomics!

If you're interested in single-cell omics and alternative splicing, we are currently recruiting a computational postdoc: mdc-berlin.de/career/jobs/po…. Please RT!

Spatial biology of cancer evolution go.nature.com/3W2m25J #Review by ✨ zaira seferbekova, Artem Lomakin, Lucy Yates & Moritz Gerstung DKFZ Wellcome Sanger Institute Free to read here: rdcu.be/c1jwe

Outstanding!!

On the evolution & function of a PanAS exon in PRC2

Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma: Cell Reports cell.com/cell-reports/f…

The peer-reviewed version of our study on the evolution of tissue-specific expression across vertebrates and insects is finally published in NatureEcoEvo ! Federica Mantica Centre for Genomic Regulation (CRG) UPF Medicine and Life Sciences nature.com/articles/s4155…

Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing biorxiv.org/content/10.110…

Cancer dysregulates thousands of exons; some are drivers and could lead to therapies. But which ones? Similar to VEP models for mutations, we model potential cancer driver exons genome-wide and predict exon fitness in cancer. Nature Communications: doi.org/10.1038/s41467… 🧵

Announcing our recent preprint on the cis-regulatory landscape shaping microexon splicing and its regulation by SRRM3/4! You can read the teaser by Manuel Irimia and delve into the detailed findings here: biorxiv.org/cgi/content/sh…

"Comprendre la història evolutiva dels nostres genomes és fonamental per avançar cap a la medicina personalitzada", diu Manuel Irimia UPF Medicine and Life Sciences. Tres institucions catalanes uneixen forces per llançar el 1er programa de genòmica mèdica evolutiva del món. ara.cat/ciencia-medi-a…

📰A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation