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Unleashing the Full Potential of Tissue-Resident NK Cells Through TGF-β1 - Darío Solís-Sayago Journal of Experimental Medicine Colin Sparano TuguesLab University of Zurich oncodaily.com/url/213590 #Cancer #ImmuneOnc #IO #ImmunoOncology #Immunotherapy #MedEd #MedX #MedNews #Health #Medicine #OncoDaily #Oncology

The findings from Colin Sparano, Darío Solís-Sayago et al. TuguesLab reveal tissue-specific regulation of trNK cell differentiation and function by autocrine TGF-β1, which is relevant for antiviral immunity. hubs.la/Q0302QQp0 #InnateImmunity #InfectiousDisease #HostDefense

Great insight summarizing what we know so far about trNK cells: from appreciating heterogeneity within group 1 ILCs to our autocrine TGF-β1 story. On point!

Check out this article I wrote with fellow postdoc Shanelle Reilly, PhD and our advisor Dr. Laurent Brossay Brown University ! New insights from TuguesLab Colin Sparano Darío Solís-Sayago : how conventional NK cells establish and maintain residency in glandular tissues

Thrilled to share my 1st brainchild, out today in Nature Genetics ! Been hearing a lot about fetal-like states lately? Here, we uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. rdcu.be/d9iSN a 🧵

Let’s not lose hope that we can find our way to a better world. It might take time but we should realize that we aren’t the product of warring #SelfishGenes but the creation of #CooperativeCells english.elpais.com/science-tech/2…

Our March cover hubs.la/Q038CHPl0 shows an immunofluorescence staining of salivary gland from MCMV-infected mice 16 days after infection. TuguesLab (hubs.la/Q038CP8T0) show that autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells

Prominentes oncólogos españoles han denunciado que pacientes cuya asistencia sanitaria depende de varios seguros médicos están viendo restringido su acceso a terapias contra el cáncer cuyo uso es “habitual en la sanidad pública” elpais.com/sociedad/2025-…

42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes doi.org/10.1002/cyto.a…

Published in Immunity, Peter Fecci lab (Duke Neurosurgery), Jan 2025. Tumor-associated macrophages (TAMs), not tumor cells, are primary mediators of progression from progenitor-exhausted to terminally-exhausted T cell state in GBM. TAM-T cell interaction are typically prolonged

Biologists have built one of the most detailed pictures of pregnancy's true toll on the body. Read the full story: go.nature.com/4hUpNES

Please check out our paper published in Nature Medicine on our Phase I trial of AFM13-precomplexed cord blood NK cells in relapsed/refractory CD30+ lymphomas. Led by Dr. Yago Nieto and an outstanding team of coauthors and collaborators, this study marks the first clinical

What if TCRs didn’t need to see peptides to bind MHC? A newly identified human TCR docks sideways onto HLA-DQ2.5—like an antibody. This could reshape how we think about antigen recognition 🧐🧐 Monash University Monash Medicine, Nursing and Health Sciences Rossjohn lab Nature Communications Congrats!

Congratulations to Will Freed Pastor Hale Family Center For Pancreatic Cancer Research on his foundational Science Magazine paper!! Totally transforms the landscape of #PancreaticCancer tumor antigens. Jacks Lab Break Through Cancer Lustgarten Foundation science.org/doi/10.1126/sc…

Uptake of polar lipids through SR-B1 drives NK cell dysfunction in ovarian cancer and can be targeted to restore NK cell cytotoxicity Science Immunology science.org/doi/10.1126/sc… Karen Slattery Lydia Lynch

Our paper Science Immunology shows certain lipids are responsible for the immunosupression of ascites & propose blocking lipid uptake thru SCARB1 may help immunotherapy success in ovarian cancer. Wonderful to collaborate with Donal Brennan again, Marcia Haigis & super postdoc Karen Slattery

Fantastic review of somatic testing in PDAC by Eileen M O’Reilly . Which are the validated biomarkers? How to test?Where we are today, where we need to be in the future…

TGF-β and IL-12 conversely orchestrate formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine cell.com/iscience/fullt…

Online Now: A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture dlvr.it/TM3kdh