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This study dissects the requirement for the miR-290 and miR-302 clusters during the reprogramming of mouse fibroblasts into induced pluripotent stem cells. academic.oup.com/stmcls/article…

Congratulations to Dr. Michael Mullen, winner of the 2024 STEM CELLS Early Career Investigator Award academic.oup.com/stmcls/pages/2…

This study investigated the molecular mechanisms that allow natural killer cells to respond to human pluripotent stem cells. doi.org/10.1093/stmcls…

This work highlights the potential therapeutic value of targeting cellular senescence pathways in the treatment of premature osteoporosis and age-related bone loss. doi.org/10.1093/stmcls…

Study investigating the role of bone marrow mononuclear cells in activating angiogenesis provides new understanding of fracture healing mechanisms. doi.org/10.1093/stmcls…

A serum- and feeder-free differentiation process, suitable for large-scale production of iPSC-derived CD4sp and regulatory T cells, is reported here. doi.org/10.1093/stmcls…

Interesting work aimed at using marsupial models for next-generation conservation and de-extinction efforts. doi.org/10.1093/stmcls…

Congratulations to our amazing colleagues UC Davis Health for this excellent review in STEM CELLS Journal! Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration academic.oup.com/stmcls/article…

Optimizing approaches for targeted integration of transgenic cassettes by integrase-mediated cassette exchange in mouse and human stem cells doi.org/10.1093/stmcls…

Senescence accelerated mouse-prone 8: a model of neuroinflammation and aging with features of sporadic Alzheimer’s disease doi.org/10.1093/stmcls…

This study demonstrated an unprecedented role of RUNX1 in regulating hematopoietic and mesenchymal fate decisions in human pluripotent stem cells-derived hematopoiesis. doi.org/10.1093/stmcls…

First study to investigate the mechanism by which METTL3-mediated pri-miRNA m6A modification regulates human adipose-derived stem cell osteogenesis, presenting a novel therapeutic approach for bone defect repair and regeneration. doi.org/10.1093/stmcls…

A small molecule K-3 promotes PDX1 expression and potentiates the differentiation of pluripotent stem cells into insulin-producing pancreatic β cells doi.org/10.1093/stmcls…

Extracellular microvesicles/exosomes—magic bullets in horizontal transfer between cells of mitochondria and molecules regulating mitochondria activity doi.org/10.1093/stmcls…

Decoding the epigenetic and transcriptional basis of direct cardiac reprogramming doi.org/10.1093/stmcls…

Consistent self-organized emergence of hyaline cartilage in hiPSC-derived multi-tissue organoids academic.oup.com/stmcls/article…

Changes in iPSC-astrocyte morphology reflect Alzheimer’s disease patient clinical markers doi.org/10.1093/stmcls…

Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson’s disease doi.org/10.1093/stmcls…

A serum- and feeder-free system to generate CD4 and regulatory T cells from human iPSCs doi.org/10.1093/stmcls…

This study makes a contribution to the understanding of the pathophysiology of Huntington's disease. The results reveal the disruptive impact of mHTT on the development of medium spiny neurons that likely contributes to neurodegeneration. doi.org/10.1093/stmcls…