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Causal inference for clinicians ebm.bmj.com/content/early/…

"Causal inference aims to determine when we can infer that associations are or are not due to causal effects." Causal inference for clinicians buff.ly/2Xjrpze #ebm BMJ Evidence-Based Medicine The BMJ

EBM learning Does my patient have SARS-CoV-2 infection? A reminder of clinical probability formulas ow.ly/Yjim50EpbAz #Coronavirus #Covid19

#TWICPodcast update You may have seen one of >3000k journal articles describing #obesity paradox: high BMI is protective in, say, AF or Heart failure That is so weird, b/c exactly zero docs tell normal-weight pts with AF or HF to eat Cheetos or donuts How can this be? 🧵

New finding: "Pediatric obesity is clearly associated with a lower diabetes risk." ncbi.nlm.nih.gov/pubmed/29374028 Yet another paradoxical association explained by #selectionbias due to selection on a #collider (diabetes test). Highly recommended paper by Stovitz, Banack, and Kaufman.

Healthy #weight was associated with 4–13 times higher relative risk of #diabetes compared with being #obese! While apparently shocking, the study’s fatal flaw (selection bias) explains the ‘paradoxical’ finding.buff.ly/2FEAFVv #obesity #epidemiology #Science #important

Thanks to Hailey Banack for a great workshop on quantitative bias analysis UCSF Epidemiology & Biostatistics yesterday. Critical not just to recognize limitations but assess plausible magnitude. Check out Hailey & @ER_Mayeda's workshop at 2018 SER conference: epiresearch.org/annual-meeting…

This should be required reading for anyone trying to do research derived from retrospective EMR data. The possible biases HAVE to be considered & understood. x.com/statsepi/statu…

This may be the most important “study” of 2018. Seriously. If you believe in the obesity paradox (or other paradoxes), read this…again and again> ncbi.nlm.nih.gov/pubmed/29374028 #SelectionBias h/t statsepi cc Prash Sanders #HealthJournalism Cedric Kanode

Does reluctance to use the word “causal” lead to scientists misrepresenting the goals & findings of their research? A new commentary calls for greater clarity of purpose & language in scientific studies goo.gl/sxUHwt