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Combined immunolabeling for tau and blood vessels in thick tissues reveals accumulation reminiscent of CAA?! This preprint describes what we've been up to recently: biorxiv.org/content/10.110…

Invisible tau and shunned neurons? A little teaser for work we have been doing with Brad Hyman and Ted Zwang. More to come soon (I hope)! alzforum.org/news/research-…

In a recent study published in the Journal of Brain, Behavior, and Immunity, researchers from MGH Neurology and colleagues investigated MS and synapse damage from inflammation. Read more: massgeneral.org/news/research-… @mghneurosci

In people w/ Alzheimer's, blood vessels are tortuous and irregular just like what we reported in tau models in 2018. In our new work, we show that there's a lot more perivascular tau than previously thought. Read about clear brains + vascular tau here: link.springer.com/article/10.100…

In Alzheimer's the presence of neurons with tau tangles is a close correlate for neuron loss BUT in new 2P longitudinal imaging work from the lab we show that neurons with tangles live while neurons without tangles die. I'm surprised, are you? @MGH_RI : cell.com/cell-reports/f…

#Twophotonmicroscopy & image analysis provides insight into relationship between #tau neurofibrillary tangles & #neurons in #Alzheimers mice model & human tissue. Image & research by Ted Zwang et al @MGH_RI Harvard Medical School in Cell Reports. On bpod.org.uk/archive/2024/9…