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Artifactual FA dimers mimic FAHFA signals in untargeted metabolomics pipelines final Journal of Lipid Research version, open access congrats Alisa Nelson, PhD @puchatek22ch Curtis "Tug" Hughey Lisa Chow jlr.org/article/S0022-…

New from our lab on the TSC protein complex, which is at the center of both the mTORC1 pathway and much of my lab's research. We describe the first mouse KO of TBC1D7, a third component of the complex. cell.com/cell-reports/f…

How does the functional proteome differ between liver cell types and in liver diseases? Find out from our dynamic and cell-type resolved human liver proteome atlas out in Mol Syst Biol. Kudos to Lili Lili Niu, Jonel @Joneltrebicka and the collaborators! doi.org/10.15252/msb.2…

Happy to share our recent manuscript using global run on sequencing (GROseq) to define the liver transcriptional response to feeding and defining the role of AKT-FOXO1 in this response. Great collaboration with Hee-Woong Lim @MitchLazar1 BBCB Graduate Group @pennidom cell.com/iscience/fullt…

Bile acids & #genetics of #insulin sensitivity. Increased circulatory Chenodeoxycholic acid due to genetically reduced CYP8B1 activity increases skeletal muscle insulin sensitivity contributing to increased whole-body insulin sensitization Journal of Clinical Investigation jci.org/articles/view/…

Don’t wait to learn programming to start analyzing your genomics datasets. There are plenty of graphical user interface tools that require 0 programming knowledge. Every student deserves to experience that aha moment and the joy of discovery 😀! Here are some of my fav tools- 🧵

There is hope…another inspiring story from the young Weiss.

Congratulations Brendan D. Manning and Aaron! Another great story!

Exciting new paper about nutrient regulation of TFE3. Congrats Chris Nardone! Really happy for you!

A new take on NAFLD progression: Defects in S1P/TREM2 signaling impair ability of macrophages to clear out dead hepatocytes. Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development cell.com/immunity/pdf/S…

Nice to see in The New York Times this nuanced discussion of the effects of alcohol intake on health, which cites our recent work led by Kiran Biddinger nytimes.com/2023/01/13/wel…

We are going to need to generate (ie clone) and amplify a few AAVs to manipulate hepatic gene expression. Any advice on companies to use?

Molecular imaging of liver inflammation using an anti-VCAM-1 nanobody - PubMed pubmed.ncbi.nlm.nih.gov/36828835/

It isn’t about NAFLD, but it’s a heartfelt genetic association. Congratulations to Shaan Khurshid and colleagues!

Congratulations! Was a treat to see this story evolve!

More fantastic work Hao Zhu and colleagues—this approach is a game changer!

Congratulations to @jkrawczyk17 for successfully defending her thesis! What a fantastic job. I am so proud of and happy for you! And thanks to @dgmashek for being on the committee!

A great opportunity for someone looking to study lipid droplets and have a lot of fun…

Today we report that removing a strain from a complex microbiome can ripple through the community in an unpredictable (& useful) way. Min Wang was the mastermind, with help from Mark Brown, Stan Hazen & crew. Cell 1/25 cell.com/cell/fulltext/…