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Excited to share our findings from an awesome @HarvardCellBio UC Berkeley MCB collaboration! Protein dislocation from the ER by the P5A-ATPase ATP13A1 (yeast Spf1) is critical for mitochondrial tail-anchored protein localization. science.sciencemag.org/content/369/65…

Our work on the ATP13A2 (PARK9) polyamine transporter associated with Parkinson's disease just appeared in Molecular Cell (authors.elsevier.com/a/1d%7Ebl3vVUP…)! Congrats @sobuelow , and thanks Eunyong Park and Sue Im Sim at UC Berkeley MCB , QB3-Berkeley for a fantastic collaboration.

It's time! Vote YES to authorize a strike and show University of California that we won't back down until they recognize our union➡️ surveymonkey.com/r/FBZ8N36 Then tell us why you're voting #SAVyes!

Check out this beautiful cover art by Dorotea Fracchiolla_Art&Science for this month's issue of Molecular Cell! Everything's better in claymation! Thank you for bringing your talent and insight to this story. You can find more of Doro's amazing work here: my-art-science.com

BREAKING - 10,890 SRs voted in our Strike Authorization Vote, and 97.5% of them voted yes. Michael V. Drake and University of California, are you paying attention?

New preprint! Structures of the channelrhodopsin ChRmine in lipids give insight into its unique channel properties and ideas for engineering new optogenetic tools. Great work by @KTckr and Savitha Sridharan and another fun collab with Hillel Adesnik! biorxiv.org/content/10.110…

BREAKING: UC agrees to recognize SRU-UAW in its entirety! This historic victory was brought about by the tireless efforts of thousands of SRs who organized to win a union & a direct response to our massive Strike Authorization Vote. Now let’s win a strong contract for all SRs!

Our lab's first tweet! We are very excited to share our new preprint on the mechanism of Sec61 translocon inhibition by small molecules (7 distinct compounds). We thank our collaborators! A common mechanism of Sec61 translocon inhibition by small molecules biorxiv.org/content/10.110…

Our story about the mitochondrial TIM23 complex is finally out nature rdcu.be/de4jn after >1.5yr revision. Great, forceful teamwork between Sue Sim and Yuanyuan Chen and fantastic collaboration with JC Gumbart's group.

Awesome to see this paper from Long Li's group on TIM23 that also highlights the role of Mgr2 in the translocase. Congratulations to all authors, especially for tackling the new terrain of characterizing the TOM-TIM23 supercomplex! biorxiv.org/content/10.110…

Check out our preprint on the Doa10 E3 ligase, the key player in ERAD-C. We combined cryo-EM, MD simulations (another cool collaboration with JC Gumbart and Diane Lynch!), and biochemical approaches to reveal how Doa10 recognizes its substrate proteins. biorxiv.org/cgi/content/sh…