EnzymeCAGE: A Geometric Foundation Model for Enzyme Retrieval with Evolutionary Insights 1. EnzymeCAGE introduces a novel framework combining enzyme structure, evolutionary insights, and chemical reactions to predict enzyme functions and retrieve enzymes for reactions. It

Brain hacks: Engineering a microbial factory for Parkinson’s disease Preview of work that engineers a microbiota-based therapeutic for sustained, non-fluctuating L-DOPA production, demonstrating therapeutic promise for PD via stable dopamine signaling cell.com/cell-host-micr…

Recovery of 1,773 microbial genomes and 2,060 viral genomes from the Mars-analog Qaidam Basin desert nature.com/articles/s4159…

Engineering T cells (CAR-T) has had marked benefits for cancer and autoimmune disease. But doing that inside the patient's body (in vivo) would make that far more practical and less expensive. cell.com/cell-reports-m…

Gut bacterial metabolism of steroid hormones Gut bacterial pathway involving OsrABC reduces natural & synthetic steroid hormones, including prednisolone. This microbial activity is enriched in Crohn’s disease patients & diminishes drug bioavailability cell.com/cell-host-micr…

Triggering infection: When microbial pathogens are in cahoots Highlight of nature paper revealing that Candida albicans, a fungus frequently found in the gut, facilitates the intestinal colonization and infection of Salmonella. cell.com/cell-host-micr…

antiSMASH database version 5 | Nucleic Acids Research | Oxford Academic academic.oup.com/nar/advance-ar…

Peptide2Mol: A Diffusion Model for Generating Small Molecules as Peptide Mimics for Targeted Protein Binding 1. Peptide2Mol introduces a novel approach to generate small molecules that mimic peptide binders, leveraging an E(3)-equivariant graph neural network diffusion model.

New online! Expansion of artificial intelligence for genome editing bit.ly/4oaUpVv

Orchestrating Spatial Transcriptomics Analysis with Bioconductor (including interoperability with Python) Paper: biorxiv.org/content/10.110… Book: bioconductor.org/books/OSTA/ #Rstats

“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.” Genes-> Medicine Nature Medicine nature.com/articles/s4159…

Use quantitative in vitro mass spectrometry to measure temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains! Cydney Martell Sevtap Savas, PhD (she/her) Gabriel Rocklin

Check out our new paper entitled "Boolean Logic-based Controlled Release of Bioactive Proteins with Diversified Inputs", live in Angewandte Chemie! Growth factors, enzymes, nanobodies, cytokines, and fluorescent proteins can now be "logically" delivered! 📜: onlinelibrary.wiley.com/doi/10.1002/an…

What decides the “winners” in a microbial community? It's not only competitive traits; rare microbes play a key role. This #mBio study offers a “nomination-voting” model, showing how rare taxa collectively shape which species become dominant. #microbiome doi.org/10.1128/mbio.0…

Multi-omics profiling reveals atypical sugar utilization and a key membrane composition regulator in Streptococcus pneumoniae | Nature Communications nature.com/articles/s4146…

In the latest issue! Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains dlvr.it/TPWKmj

Out Now! A human gut metagenome-assembled genome catalogue spanning 41 countries supports genome-scale metabolic models bit.ly/3Y7yKmz #Metagenomics #HumanGutMicrobiome #MicrobialGenomics

The Microflora Danica atlas of Danish environmental microbiomes | Nature nature.com/articles/s4158…