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Collagen-IV networks rule the #mechanics of our epithelia, but we know little about how they reshape. Our new preprint (with the 1st coarse-grained MD models of #collagen-IV!) shows how consuming energy during remodelling might make the difference: 📑tiny.cc/s6fqzz 🧵

Excited to release our latest work, led by Alejandro Martínez Calvo: arxiv.org/abs/2411.14636! Here, we characterize the rich dynamics of surface-attached "active drops", and develop principles to predict & control their shape and motion (morphodynamics). 💧🦠 Tweetorial follows... [1/6]

🎉 Thrilled to share the @ribacklab’s first PhD defense! Huge congrats to Gandhar Datar and co-advisor Peggy Goodell ! 🎓🔬 Gandhar’s work in biophysics and leukemia led to the discovery of a new phase-separated condensate that drives leukemias. Stay tuned for more insights!

Little big step towards better live cell imaging.

Meet the CALVADOS RNA model on bioRxiv or on 🦋

Why are so many proteins hyper-phosphorylated during mitosis? Well, phosphorylation renders individual proteins more soluble & disrupts protein-protein interactions. So global hyper-phosphorylation may 𝐟𝐥𝐮𝐢𝐝𝐢𝐳𝐞 the cytoplasm - to mechanically aide cell division.

Check out Rasmus Krogh Norrild's work with Alex Buell @biophysics_dtu and Joseph Rogers developing and using Condensate Partitioning by mRNA-Display to probe phase separation of ~100.000 sequences, and @SoBuelow simulations to support and analyse the experiments

1/ Pleased to share our review, published today Nature Rev Immunol, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. nature.com/articles/s4157…

Nanometer condensate organization in live cells derived from partitioning measurements biorxiv.org/content/10.110…

New preprint from the lab! With Brumbaugh Lab, we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. biorxiv.org/content/10.110…

Probing condensate microenvironments with a micropeptide killswitch: nature.com/articles/s4158…

If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments. biorxiv.org/content/10.110…

Finally sharing new work posted on biorxiv. We find that hydration free energy can serve as a quick and dirty approximation for globular protein partitioning into condensates. We also present a comparison of different hydration free energy methods. biorxiv.org/content/10.110…

Josh Riback Looks like a well-seasoned and juicy nucleolus!! Have fun!