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HLA-I–restricted peptide recognition is a critical feature of some KIR and may influence NK cell responses to disease Malcolm Sim science.org/doi/10.1126/sc…

Sytse Piersma (Sytse Piersma), Sushant Bangru (Sushant Bangru), Yokoyama and colleagues identify a crucial role for post-transcriptional regulation by HuR in NK cell proliferation, which is required for control of long-term virus infection and solid tumors. bit.ly/44Tzflg

In Journal of Experimental Medicine, Sytse Piersma Sytse Piersma, Sushant Bangru Sushant Bangru, Yokoyama et al. identify a crucial role for post-transcriptional regulation by HuR in NK cell proliferation, which is required for control of long-term virus infection and solid tumors. bit.ly/44Tzflg

Thrilled to see our story out on HuR-dependent NK cell proliferation in virus infection and tumor control out in Journal of Experimental Medicine. Big thanks to everybody making this study possible, including our collaborators Sushant Bangru and Kalsotra Lab at Biochemistry at Illinois. bit.ly/44Tzflg

.Sytse Piersma, Sushant Bangru, Kalsotra Lab, Yokoyama Test Account and colleagues reveal that HuR-dependent NK cell expansion is required for control of long-term virus infection and solid tumors without affecting acute infection or tumor metastases. bit.ly/44Tzflg

ITAM-based receptors in NK cells Oscar A. Aguilar, PhD doi.org/10.1111/imr.13…

In this article, we provide a brief perspective of the promise of allogeneic cell therapies against cancer. We consider rejection by the recipient as a central pitfall and discuss approaches to reduce this rejection by genetic engineering nature.com/articles/s4157…

Tissue-specific features of ILCs in antiviral defense REVIEW by Sytse Piersma nature.com/articles/s4142…

Online now in Cellular and Molecular Immunology: my review on the role of ILCs in virus infection with a focus on tissue specific features. nature.com/articles/s4142…

Trans Antigen Signaling Receptors (TASR) as a new class of NK inhibitory ligands and discovered universal capacity forCD300a to protect allogeneic T cells from NK cells biorxiv.org/content/10.110…

Cryopreservation protocols optimized for T cells kill ~75% of NK cells w/in 24 h of thaw due to leakage of GzmB from vesicles. This is prevented by IL15/IL-18 pretreatment to ⬆️antiapoptotic genes & deplete gzmB containing granules [Berjis & Sheppard] nature.com/articles/s4146…

CD8α status identifies human NK cell capacity for IL-15-induced proliferation and metabolism in a time-dependent fashion and exhibits a suppressive effect on NK cell activating receptors Journal of Clinical Investigation Fehniger Lab Celia Cubitt jci.org/articles/view/…

NK cells were first described five decades ago and named in 1975. This brief Perspective from Lewis Lanier UC San Francisco highlights a timeline of a few selected advancements in NK cell biology in each decade. hubs.la/Q02zRMB70 🎥 See video summary: hubs.la/Q02zRKh80

Expression of Ly49A alone on a H-2Dd background restored missing-self target cell rejection, NK cell licensing, and NK cell KLRG1 expression, therefore a single inhibitory Ly49 receptor is sufficient to license NK cells Sytse Piersma #Yokoyama doi.org/10.1101/2024.0…

Cis-regulatory evolution of the recently expanded Ly49 gene family Nature Communications Ting Wang Sytse Piersma #Yokoyama Changxu Fan nature.com/articles/s4146…

I have waited for this moment my entire PhD for Waggoner Lab to tweet about my work!!

NK cell IFNγ induces resistance of tumors to NK cells by upregulating classical & non-classical MHC-I, where therapeutic combination of monalizumab/lirilumab/DX9 may fully restore the antitumor response across NK cell subsets Tomáš Hofman 🍅 Cerwenka Lab jitc.bmj.com/content/12/7/e…

Happy to share the final work from my post-doc with MalmbergLab published in Cell Stem Cell today cell.com/cell-stem-cell… extensive 15-post-🧵 below

I am pleased to share with you that my paper has been accepted in Nature rdcu.be/dOPyr This work would not have been possible without the guidance of an exceptional mentor, support of awesome lab members and collaborators. WashU Medicine Pathology & Immunology Education Natera Parker Institute for Cancer Immunotherapy