🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Fatigue (HR 1.98, p=0.024) and poor sleep (HR 2.19, p=0.004) at epilepsy diagnosis predict ASM resistance. Depression severity mediated 18.5% (fatigue) and 23.7% (sleep) of the effect. 🔗 journals.sagepub.com/doi/epdf/10.11…

In RRMS, 6 months of dimethyl fumarate therapy significantly altered gut microbiota composition, increasing Firmicutes families and reducing Bacteroidetes and Proteobacteria. Pre-treatment profiles predicted both 1-year disease activity and adverse events journals.sagepub.com/doi/epdf/10.11…

🧪 In early Parkinson’s disease, higher baseline plasma NfL levels were linked to both persistent and new-onset fatigue at 2-year follow-up. NfL may serve as a predictive biomarker for fatigue subtype conversion in PD. Read here: journals.sagepub.com/doi/epdf/10.11…

🚨 A meta-analysis of 26 trials (160k+ participants) suggests GLP-1 drugs (like semaglutide in Ozempic/Wegovy) may significantly reduce dementia risk—potentially via anti-inflammatory effects, not just glucose control. 🧠 More via New Scientist: newscientist.com/article/247530…

📊 In this US claims study (n=1,568), natalizumab as first-line MS therapy cut relapse rates more than later-line use (ARR: 1.48→0.28 vs 0.92→0.41) and showed greater reductions in hospital stays, ER visits, and outpatient use. doi.org/10.1177/175628…

📉 In 14 MuSK-MG patients, efgartigimod reduced MG-ADL scores from 10.1 to 2.2 by week 4 (p=0.001); 93% maintained benefit >8wks, and 71% reached minimal symptom expression by week 12. Lower steroid needs with CD20/tacrolimus combo. doi.org/10.1177/175628…

📡 In a patient with refractory epilepsy, personalized ANT-DBS settings (125 Hz, 50 μs) suppressed theta/alpha activity more than standard clinical settings (145 Hz, 90 μs). Gamma suppression in-clinic also linked to >50% seizure reduction over 1 year. doi.org/10.1177/175628…

In this proof-of-concept study, researchers treat mice with spinal muscular atrophy using in utero antisense oligonucleotides: statnews.com/2025/05/14/spi… #GeneTherapy

📊 In a 13-year real-world study of 3850 MS/NMOSD DMT courses, 24.2% were stopped due to AEs. Just 1.7% were atypical, 3.1% unusually severe—spotlighting rare but impactful safety signals. 🔗 journals.sagepub.com/doi/epdf/10.11… #NeuroTwitter #MS #NMOSD

Staying active is important for brain health, but for people with #Parkinsondy’s disease (PD), regular intense exercise can be challenging. This study suggests that walking even 1-2 times a week can reduce the risk of #dementia: journals.sagepub.com/doi/epub/10.11…

What is the impact of systolic blood pressure at admission on the short-term outcomes after dual antiplatelet therapy in patients with minor ischemic #stroke or transient ischemic attack? Findings by the READAPT study group here: journals.sagepub.com/doi/full/10.11…

Could colchicine or GLP-1R agonists have a role in secondary #stroke prevention? Read more about existing evidence in this Review: by Milija Mijajlovic, Natan Bornstein & Aleksic Vuk: journals.sagepub.com/doi/full/10.11…

In another article discussing GLP-1R agonists (you may have spotted there's a theme...), Junchen Si and colleagues discuss the mechanisms of their therapeutic effects in neurocognitive disorders: journals.sagepub.com/doi/full/10.11…