🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

How has #biocatalysis evolved in the past 5 years? Our just-published review in Science Magazine highlights how powerful technologies have enabled scientists to dream up bold new-to-nature activities and bring them to biocatalytic reality. Curious? 👉science.org/doi/10.1126/sc…

Starting off the year with some exciting news! Thrilled to say my first ever cover art is on the cover of Chemical Reviews this month! Our review was submitted as part of a thematic issue about late stage functionalisation, go check it out if you haven't already :) The Larrosa Group

🎉The Blavatnik Awards and @nyasciences are excited to announce the Honourees of the 2024 Blavatnik Awards in the UK! Please join us in congratulating these nine incredible scientists sparking innovations that will transform our future world. Learn more: blavatnikawards.org/news/items/pre…

A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzyme nature.com/articles/s4146…

🚀Exciting PhD opportunity alert! Dive into ground breaking research with a Oct 2024 start. We're exploring innovative synthetic chemistry on-DNA🧬for DNA-encoded libraries. Transform the future of chemistry! Deadline 15 March 2024. Details: tinyurl.com/4f3d8f66 #PhDPosition

The Larrosa Group in Bristol Synthesis Meeting! Amazing day with 5 Top level speakers

Excited to share our Chem Rev article! Here we describe how site specific incorporation of non-canonical amino acids has enabled mechanistic studies, improved existing functions & provided a strategy for embedding new modes of catalysis into active sites pubs.acs.org/doi/10.1021/ac…

Arguably the coolest chemistry we’ve uncovered yet ChemRxiv, especially given that it’s with just one metal!! 🤯Fantastic work by Stas Melnikovᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠᅠ and first of many collabs with Baik Group | Hydride as a Leaving Group in Nucleophilic Aromatic Substitution | - go.shr.lc/3ycdkeL

Today we're joined by Gillian McArthur (Larrossa group), who shares the incredible story behind the development of an air and moisture stable catalyst, RuAqua!! Link: youtu.be/g2xHSLJIO8U Key paper: Nature Chemistry doi.org/10.1038/s41557…

📢 Finally out in J. Am. Chem. Soc.: We engineered the first #PhotoLanZyme, a lanthanide-dependent photoredox enzyme that catalyzes radical C-C bond cleavages upon visible-light irradiation! 💡🧫🧪🧬💻 TU München European Research Council (ERC) pubs.acs.org/doi/10.1021/ja…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

The story of how I developed the first biocatalysts for convergent and stereoselective SNAr chemistry is out now in nature! A massive thank you to all of the contributing authors from Green Research Group and The Larrosa Group 🤓 nature.com/articles/s4158…

Delighted to announce that 'Engineered enzymes for enantioselective nucleophilic aromatic substitutions' is out now in Nature! Congratulations to Tom, George and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s4158…

We are so excited to share our collaborative work with the Green Research Group, on the development of biocatalysts for enantioselective SNAr reactions, just out in nature!! Massive congrats to Tom, Tom, and all co-workers! 👏 See: rdcu.be/d6moS

#ProcterPOW: our colleagues Green Research Group report an enzymatic enantioselective SNAr to give a variety of products and building enantiopure quat centres. Engineering 🧬 of the active site leads to a 31-fold increase in conv and 91% increase in ee! 🔗👇

Just out in John Callahan, we report mechanistic studies on the photoexcitation of biscyclometalated-Ru species and their role in photocatalyzed C-H alkylations with epoxides. Congratulations to Kurt and co-workers, Team Natrajan and Golovanov group!! pubs.acs.org/doi/10.1021/ja…

Photoredox-Catalyzed Nucleophilic Aromatic Substitution of Halophenols with Azoles via Oligomeric Phenylene Oxide Radicals | Journal of the American Chemical Society Total Synthesis and Methodology Highlights Princeton Chemistry Princeton University pubs.acs.org/doi/10.1021/ja…

KFB Lab Alert: Our latest work applying enzymatic halide recycling to thioketal cleavage is now available ChemRxiv! Congratulations to Manik Sharma and Yue Li on this work! chemrxiv.org/engage/chemrxi…

Very happy to announce that 'Efficient and selective energy transfer photoenzymes powered by visible light' is out today in Nature Chemistry! Congratulations to Rebecca, Ross and everyone else involved in this project! 🎉🎉🎉 nature.com/articles/s4155…

Enantiodivergent Access to Acyclic Quaternary Stereocenters by Nitrilase-Catalyzed Desymmetrizing Hydrolysis of Malononitriles | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…