Walking is an essential part of life- yet we do not know how the nervous system generates the underlying neural programs. Please find our sneak-peek preprint on neural generation of locomotion in the mouse: biorxiv.org/content/10.110… Pan-neuronal 1-spot tracks in lumbar cord

Discovery of neuronal cell types by pairing whole cell reconstructions with RNA expression profiles biorxiv.org/cgi/content/sh… #biorxiv_neursci

🔥 Inflammation and neuron protection In aging brains, genes associated with inflammation became more active, while those related to neuronal structure and function decreased. Read the publication📜 nature.com/articles/s4158…

🎯 Aging hot spot in the hypothalamus The most drastic gene expression changes were found in the third ventricle of the hypothalamus.

Our #bionformatics #Rstats method CRAWDAD (Cell-type Relationship Analysis Workflow Done Across Distances) for quantifying cell-type spatial relationships in #singlecell #spatialomics data is now published! nature.com/articles/s4146… Congrats to the team 🥳🥂 #AcademicTwitter

Are you using 5xFAD mice to study Alzheimer’s disease? Our work Neuron may be relevant to you 🐁 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. (1/11) cell.com/neuron/fulltex…

How cool is this? Michal Lipinski from Broad Institute presenting stacked #Illumina spatial slides of the mouse brain with subcellular transcriptome resolution #AGBTGM

Hiroki R. Ueda すいしぇ/Susaki EA Our 3D whole-brain single-neuron atlas is now available on GitHub! This atlas integrates spatial information of every cell in the mouse brain within the Allen Brain Atlas CCFv3. Our paper links it with spatial transcriptomics dataset. github.com/OrganismalSyst…

Can we predict future brain activity in a small vertebrate?🤔 We're releasing ZAPBench⚡️(#ICLR2025 spotlight): a benchmark to forecast activity in a whole vertebrate brain🧠 at single-cell resolution!🐟 70k+ neurons, 3 TB of data & extensive baselines. Connectome is coming! 🧵👇

Advances in neuroscience have yielded massive, rich datasets from various analysis techniques and modalities. In a Nature Neuroscience perspective, researchers underscore the importance of an integrative approach to render a more complete picture of the brain. nature.com/articles/s4159…

🥼 Janelia researchers led by Boaz Mohar (@[email protected]), Nelson Spruston, Luke Lavis & karel svoboda Allen Institute have developed a new imaging tool that maps brain-wide changes in neuronal connections. 🧠 🔗 janelia.org/news/new-imagi…

Our April issue is live! 🌧️🌷 nature.com/nmeth/volumes/… On the cover, Spotiphy projects scRNA-seq and histological image data onto the spatial transcriptome. Artwork by Jiyuan Yang St. Jude Research. Paper: nature.com/articles/s4159…

🚨 New in Nature Communications: We present a spatial multi-omics platform that maps the metabolome, lipidome, and glycome from a single brain section. Combining MALDI imaging with our computational tool Sami, we reveal metabolic diversity in health and Alzheimer's disease. 🔗

The Hidden Chaos Behind Beautiful Bioinformatics Figures 1/15 You only see the final beautiful figure in that bioinformatics paper. But behind every clean heatmap lies a storm of trials, errors, and late-night debugging sessions.

The MOSAIC reconfigurable microscope by Eric Betzig et al is finally out! MOSAIC integrates multiple advanced imaging techniques including light-sheet, label-free, super-resolution, and multi-photon, all equipped with adaptive optics: biorxiv.org/content/10.110…

Our first paper to characterize oxytocin receptor expressing neurons in the dorsal endopiriform nucleus as a part of the claustrum complex in mice is out. sciencedirect.com/science/articl…

A brief guide to statistical analysis of grouped data in preclinical research go.nature.com/4ncNcVJ

We’re entering a new era in brain modulation where we may able to treat brain disease and improve mental health with no wires and no genetic engineering. This study shows that it’s possible to noninvasively rewire neural activity using near-infrared light and systemically

2次元MALDI質量分析imaging dataから3次元脳代謝mapを自動生成するAI framework MetaVision3Dを開発 Enhanced Correlation Coefficient最大化で世界初の3次元mouse脳代謝atlas構築 AD/pompe病modelの空間分布も記載 👇map metavision3d.rc.ufl.edu #metabolism #papers doi.org/10.1038/s42255…

A derivative of the ancient drug salicylate for obesity treatment go.nature.com/44qfOCx