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Thrilled to announce that our project has been published in Cell. In this work, we link mitochondrial dynamics to mitochondrial quality control and mtDNA maintenance by characterizing the molecular function of MTFP1. Please DM; happy to discuss! cell.com/cell/fulltext/…

We present: 'Multispectral live-cell imaging with uncompromised spatiotemporal resolution'. biorxiv.org/content/10.110… 1/16

Online Now: Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress dlvr.it/T9K69n

🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬embopress.org/doi/full/10.10… #Mitochondria #microscopy #microfluidics #mtDNA

Thanks for highlighting our recent investigations at PrudentLab !

1/n 🚨 🧬Our paper on the role of #mitochondria and free radicals in promoting the collapse of #Cancer #micronuclei is out in Science Magazine today. A story led by the brilliant Melody Di Bona it started with a simple question: why do micronuclei rupture? science.org/doi/10.1126/sc…

Very excited to share our latest paper out today Nature Metabolism showing that #mitochondria transfer and transplantation may reduce the morbidity and mortality of #LeighSyndrome, a fatal mitochondrial disease with no effective therapies. dlvr.it/TCjPl6

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Many novel Asgard genomes, cultivated Lokiarchaeia, new phylogenetic analyses: what insights do these and other recent studies provide into the enigmatic origin of eukaryotes? In this review in nature , we discuss the latest findings and open questions: nature.com/articles/s4158…

Bacterium: “Archaea? Yeah, they’re alright. Quiet, peace-lovi....aaaargggh, STOP! STOP IT! WHAT IS HAPPENING??” [silence] Archaeon: “Mwahahaha” (probably) Discover the dark side of archaea in our latest pre-print, led by Romain Strock biorxiv.org/content/10.110… 1/10

Please check out our latest collaboration with Robert Pitceathly! Congrats to everyone, especially the Twitterless Micol!

How can we build an Al Virtual Cell 🔮🧬 that simulates all functions and interactions of a cell? How will it transform research and drive breakthroughs in programmable biology, drug discovery and personalized medicine? 🚀 Take a look at our Perspective! arxiv.org/pdf/2409.11654

Nice paper and thread

After some time working on it, I'm very happy and proud to share our study characterising the diversity of origins of the LECA gene families! Marina Marcet Saioa Manzano-Morales Toni Gabaldón gabaldonlab

Please have a look at our recent review on mito-dynamics!

A new study by the lab of DoM's Dr. Joel Dacks and others may uncover the ancient origins of key immune machinery ualberta.ca/en/department-… UAlberta Med & Dent PNASNews @DacksLab1 Paul Manna Narmin Kassam Canadian Soc. Micro. The CIMR

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024.1…), and Gabriel (Gav) Sturm et al. dissect the biophysics behind it (doi.org/10.1101/2024.1…). Details below! 🔬🧵

1/🧵for our latest research now out as a preprint on #biorxiv, led by Eloïse Marques 💫 **An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo** #mitochondria #immunometabolism #macrophages 📄Read here: biorxiv.org/content/10.110…

📢Paper alert!! We are excited to share our latest publication in the Journal of Molecular Biology: The PKA signaling pathway regulates the association of the autophagy initiation complex with the lipidation machinery. pubmed.ncbi.nlm.nih.gov/39826713/ IIBM Miranda Bueno-Arribas