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Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction Caltech Caltech Chemistry & Chemical Engineering #DNA #StimulusResponsive #Growth pubs.acs.org/doi/10.1021/ja…

Delighted to finally share our work on BacPROTACs, published today Cell! We bring the PROTAC approach to the bacterial world, hijacking ClpCP proteolytic complexes to induce targeted protein degradation. Read the full article here👇 authors.elsevier.com/sd/article/S00…

How is the separation of two DNA strands nucleated after the initiation of chromosome replication in eukaryotes? We were curious too... You can read about what we found here nature – a sneak peak👇 nature.com/articles/s4158… 1/4

New work led by Eva Absmeier and Vish Chandrasekaran shows how human CCR4-NOT recognises slow-moving ribosomes in codon-optimality decay. Francis O'Reilly Rappsilber laboratory European Research Council (ERC) @MRC_LMB

Excited to share our latest story: We show that JIP3 is a dynein activating adaptor. Its short coiled coil is sufficient to recruit two dyneins and activate long distance movement! Work by Kashish Singh & Clinton Lau in collab with Gassmann lab Reto Gassmann biorxiv.org/content/10.110…

1/8 We report our work on the E2/E3 hybrid BIRC6, an essential guardian of apoptosis and negative regulator of autophagy. Credit and gratitude to @DanGrabarczyk and @clausen_lab. biorxiv.org/content/10.110…

A single neural network that predicts for protein-DNA complex structures, protein-RNA complex structures, and RNA tertiary structures. Minkyung Baek Ryan McHugh, Ivan Anishchenko, David Baker, Frank DiMaio Institute for Protein Design biorxiv.org/content/10.110…

I am happy to share our latest study on the mechanism of the Anaphase promoting complex just out now in NatureStructMolBiol. This is a close collaboration with the Brown lab UNC-Chapel Hill, spearheaded by the amazing Tatyana Bodrug , who bridged the project across an ocean. nature.com/articles/s4159…

Delighted to share my first first-author paper in Science Advances 🥳We determined the structure of H2O2-activated ATM bound to p53 peptide substrate and suggest a mechanism for ATM activation by oxidative stress.🧵(1/11) science.org/doi/full/10.11…

Our work on Mad2 conversion is now live on biorxiv! Great collaboration with Élyse Fischer Joe Greener and David Barford @MRC_LMB biorxiv.org/content/10.110…

Our latest work on FANCD2-FANCI (D2-I), a complex that helps resolve DNA crosslinks and replication stress, is out! nature.com/articles/s4158… We show D2-I acts as a sliding clamp on DNA, stalling at single-stranded gaps to identify and protect damage sites. Lori Passmore David Rueda