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Posted on Alzforum Chakrabarty S, Wang S, Roychowdhury T, Ginsberg SD, Chiosis G. Introducing dysfunctional Protein-Protein Interactome (dfPPI) - A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease. Curr Opin Struct Biol. 2024

Special Issue #ProteinNetworks by The Colombo Lab Dr. Fuxreiter Università di Padova Dr. Emili Collaboratory for Network Systems Biology Dr. Kastritis Panagiotis Kastritis Dina Schneidman Cesar Ramirez-Sarmiento @cesarramirez.bsky.social Richard Doveston Dr. Vlassakis Rice University Bioengineering Dr. Nyarko Oregon State University Cerda Lab Dr. Komives UC San Diego Ion Petre Chiosis Lab et al

Transient promoter interactions modulate developmental gene activation dlvr.it/TGcZl9

Check out this video byte highlighting how #epichaperomes drive adaptability in #cancer and #stemcells! Adapted from Chiosis Lab recent publication in Nature Communications #signaling #proliferation #adaptation #proteinproteininteractions Video produced by AJE: American Journal Experts

Watch the "How epichaperomes drive adaptability in cancer and stem cells" video byte produced by AJE: American Journal Experts here: youtu.be/L37A4O6gYMk?si… #posttranslationalmodification #signaling #proliferation #adaptation #NatureCommunications #cellsignaling #epichaperomes #chaperone

And read the article in Nature Communications here: doi.org/10.1038/s41467… to further dive into how #phosphorylation can impact the conformation of the ubiquitous protein #HSP90 thus opening therapeutic avenues & drugging the undruggable #epichaperome #CancerResearch #PrecisionMedicine

New! Online now: Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis dlvr.it/TGcnH9

A genome-wide screen identifies silencers with distinct chromatin properties and mechanisms of repression dlvr.it/TGdzj1

How do stressors remodel brain function before symptoms emerge? 💫Preprint live now - our recent research on #Alzheimers & #epichaperomes! Find out how #epichaperomes are key mediators of molecular collapse in #AD & what #therapeutic avenues may be open🧠 researchsquare.com/article/rs-593…

🧠Beyond the Headlines: Ensuring Integrity While Advancing #Alzheimers Research Sensational headlines aren’t the answer. Accountability matters—but so does celebrating the science driving real solutions. communities.springernature.com/posts/beyond-t… #BiomedicalResearch #Neurodegeneration

Happy International Women’s Day! We’re celebrating women who have changed the world. Here are all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award. Tell us about the women who inspire you the most - and why

MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling dlvr.it/TK3pY5

Online Now: Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement dlvr.it/TK4qSV

Online Now: Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II dlvr.it/TKCwtb

Base-pair resolution reveals clustered R-loops and DNA damage-susceptible R-loops dlvr.it/TKHRMP

🔍Specialized #ChemicalProbes are central to dfPPI, capturing dysfunctional interactions—trapping thousands of protein interactors, enabling precise identification of disease-driven interactome changes. #MassSpec #Proteomics (4)

🧵Follow this thread by Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in Nature Communications (1/8) #cancer #phosphorylation #epichaperome #conformation #cellstress nature.com/articles/s4146…

The first direct observation of gravitational waves captured the merging of two black holes which emitted 36 septillion yottawatts of power (3.6×10⁴⁹ watts), greater than the combined power of all light radiated by all the stars in the observable universe. [🎞️ SXS simulation]

"If you're not failing, you're not pushing boundaries." Hear medicine laureate Elizabeth Blackburn speak about the valuable lessons we can learn from failure. #NobelPrize

cell.com/molecular-cell…